• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neuroscience: An International Journal under the Editorial Direction of IBRO >SOCIAL REGULATION OF ADULT NEUROGENESIS IN A EUSOCIAL MAMMAL
【24h】

SOCIAL REGULATION OF ADULT NEUROGENESIS IN A EUSOCIAL MAMMAL

机译：正常哺乳动物中成人神经发生的社会调控

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The present study examined the effects of social status on adult neurogenesis in an extreme cooperative breeder: the naked mole rat. These animals live in large colonies of up to 300 individuals, with a strict reproductive dominance hierarchy; one female and one to three males breed, and all other members are socially subordinate and reproductively suppressed. We examined the effects of social and gonadal cues on doublecortin (DCX; a marker for immature neurons) immunoreactivity in the dentate gyrus (DG), piriform cortex (PCx) and basolateral amygdala (BLA) by comparing dominant breeding animals to non-breeding subordinates from intact colonies. We also examined DCX expression in subordinate animals that had been removed from their colony and paired with an opposite- or same-sex conspecific for 6 months. Compared to subordinates, dominant breeders had significantly reduced DCX immunoreactivity in all brain areas, with BLA effects confined to females. By contrast, the effects of same- versus opposite-sex housing were region-specific. In the DG and PCx, more DCX immunoreactivity was observed for opposite- than same-sex-paired subordinates. Conversely, same-sex-paired females had more DCX immunoreactivity than opposite-sex-paired females in the BLA. Gonadectomy did not affect DCX expression in opposite-sex-paired animals, and no significant relationships between gonadal steroids and DCX immunoreactivity were detected, suggesting that group differences in neurogenesis are independent of gonadal hormones. The apparent lower neurogenic capacity displayed by breeders contrasts previous reports on neurogenesis and social rank, challenging the conventional view that subordination is stressful and impairs neurogenesis. Future work will clarify whether the present findings can be attributed to status-dependent differences in stress, behavioral plasticity, or life stage.
机译：本研究检查了社会状态对极端合作饲养者：裸mole鼠的成年神经发生的影响。这些动物生活在多达300个个体的大型殖民地中，具有严格的生殖优势等级。一只雌性和一到三只雄性繁殖，所有其他成员在社会上都是从属的，并且在生殖上受到压制。通过比较优势繁殖动物与非繁殖下属，我们研究了社交和性腺线索对齿状回（DG），梨状皮层（PCx）和基底外侧杏仁核（BLA）中双皮质素（DCX;未成熟神经元标记）免疫反应的影响。来自完整的殖民地。我们还检查了下属动物中DCX的表达，这些动物已从其殖民地中移出并与同性或异性同种配对6个月。与下属相比，优势育种者在所有脑区域都显着降低了DCX免疫反应性，而BLA的作用仅限于雌性。相比之下，同性和异性住房的影响是区域特定的。在DG和PCx中，与同性配对的下属相比，观察到的DCX免疫反应性更高。相反，在BLA中，同性配对的女性比同性配对的女性具有更多的DCX免疫反应性。性腺切除术不影响异性配对动物的DCX表达，并且未检测到性腺类固醇与DCX免疫反应性之间的显着相关性，这表明神经发生的群体差异与性腺激素无关。育种者表现出的明显较低的神经源性能力与先前有关神经发生和社会地位的报道形成对比，挑战了从属带来压力并损害神经发生的传统观点。未来的工作将澄清目前的发现是否可以归因于压力，行为可塑性或生命阶段中与状态有关的差异。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号