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首页> 外文期刊>Neuroscience: An International Journal under the Editorial Direction of IBRO >HEMOKININ-1 MEDIATES PRURICEPTIVE PROCESSING IN THE RAT SPINAL CORD
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HEMOKININ-1 MEDIATES PRURICEPTIVE PROCESSING IN THE RAT SPINAL CORD

机译：Hemokinin-1介导大鼠脊髓的保护性加工。

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Hemokinin-1 (HK-1) is a new mammalian tachykinin peptide consisting of the amino acid sequence similar to substance P (SP). Although the function of SP, a representative tachykinin peptide, has been well established in the pain system, that of HK-1 has not yet been elucidated. [Leu(11)]-SP had an antagonistic effect on SP-induced scratching behavior, suggesting that [Leu(11)]-HK-1 may also attenuate the induction of scratching behavior by HK-1. Thus, the effects of a pretreatment with [Leu(11)]-HK-1 were evaluated to clarify the function of HK-1. The intrathecal administration of [Leu(11)]-HK-1 attenuated the induction of scratching by HK-1, but not SP, while [Leu(11)]-SP reduced the induction of scratching by SP, but not HK-1. These results indicated that [Leu(11)]-HK-1 may be a more specific antagonist of HK-1-preferred receptors and [Leu(11)]-SP has an antagonistic effect on the SP-preferred receptor, the neurokinin 1 receptor. In the formalin test for examining noxious response, the intrathecal administration of [Leu(11)]-SP, but not [Leu(11)]-HK-1, reduced the number of flinchings and c-Fos-positive cells in the spinal dorsal horn following formalin injection into the plantar region of the hind paw. These results indicated that SP, but not HK-1, is involved in nociceptive processing at the spinal level. To evaluate the involvement of HK-1 and SP in pruritic processing, the effect of [Leu(11)]-HK-1 and [Leu(11)]-SP on the induction of scratching behavior and c-Fos expression by serotonin (5-HT) and histamine was evaluated. The increased induction of scratching behavior and c-Fos expression by 5-HT and histamine was markedly attenuated by pretreatment with both [Leu(11)]-HK-1 and [Leu(11)]-SP, suggesting that HK-1 and SP may be involved in pruritic processing. These results indicate that HK-1 is involved in pruritic processing and [Leu(11)]-HK-1 is a valuable tool for clarifying the mechanisms underlying pruritic processing. (C) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.
机译：Hemokinin-1（HK-1）是一种新的哺乳动物速激肽，由类似于P物质（SP）的氨基酸序列组成。尽管SP（一种典型的速激肽肽）的功能已在疼痛系统中确立，但HK-1的功能尚未阐明。 [Leu（11）]-SP对SP诱导的抓挠行为具有拮抗作用，表明[Leu（11）]-HK-1也可能减弱HK-1对抓挠行为的诱导。因此，评估了用[Leu（11）]-HK-1进行预处理的效果，以阐明HK-1的功能。鞘内注射[Leu（11）]-HK-1可以减弱HK-1而不是SP的挠性诱导，而[Leu（11）]-SP可以降低SP而不是HK-1的挠性诱导。 。这些结果表明[Leu（11）]-HK-1可能是HK-1首选受体的更特异性拮抗剂，[Leu（11）]-SP对SP首选受体神经激肽1具有拮抗作用。受体。在用于检查有害反应的福尔马林测试中，鞘内注射[Leu（11）]-SP而不是[Leu（11）]-HK-1可以减少脊髓中退缩和c-Fos阳性细胞的数量福尔马林注射入后爪足底区域后的背角。这些结果表明SP，但不是HK-1，参与了脊髓水平的伤害性加工。为了评估HK-1和SP在瘙痒性处理中的作用，[Leu（11）]-HK-1和[Leu（11）]-SP对5-羟色胺诱导的抓挠行为和c-Fos表达的影响（评价了5-HT）和组胺。用[Leu（11）]-HK-1和[Leu（11）]-SP预处理显着减弱了5-HT和组胺对induction抓行为和c-Fos表达的诱导诱导作用，这表明HK-1和SP可能参与瘙痒处理。这些结果表明，HK-1参与了瘙痒症的处理，[Leu（11）]-HK-1是阐明瘙痒症处理机制的有价值的工具。 （C）2014年IBRO。由Elsevier Ltd.出版。保留所有权利。

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