Histone H2a mRNA interacts with Lin28 and contains a Lin28-dependent posttranscriptional regulatory element.

Xu Bingsen; Huang Yingqun

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Histone H2a mRNA interacts with Lin28 and contains a Lin28-dependent posttranscriptional regulatory element.

机译：组蛋白H2a mRNA与Lin28相互作用，并包含Lin28依赖性的转录后调控元件。

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Lin28 has been shown to block the processing of let-7 microRNAs implicated in the regulation of cell growth and differentiation. Here, we show that Lin28 also specifically associates with ribonucleoprotein particles containing the replication-dependent histone H2a mRNA in mouse embryonic stem cells. We further show that the coding region of H2a mRNA harbors high affinity binding sequences for Lin28 and that these sequences stimulate the expression of reporter genes in a Lin28-dependent manner. We suggest that a key function of Lin28 in the maintenance of pluripotency is to promote the expression of the H2a gene (and perhaps also other replication-dependent histone genes) at the posttranscriptional level in order to coordinate histone production with the unique proliferative properties of embryonic stem cells.

机译：已经证明，Lin28阻断了let-7 microRNA的加工，而let-7 microRNA参与了细胞生长和分化的调控。在这里，我们显示Lin28还与小鼠胚胎干细胞中含有复制依赖的组蛋白H2a mRNA的核糖核蛋白颗粒特异性结合。我们进一步显示，H2a mRNA的编码区具有Lin28的高亲和力结合序列，并且这些序列以Lin28依赖性的方式刺激报告基因的表达。我们建议，Lin28在维持多能性中的关键功能是在转录后水平上促进H2a基因（可能还有其他复制依赖性组蛋白基因）的表达，从而协调组蛋白的产生与胚胎的独特增殖特性干细胞。

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《Nucleic Acids Research》 |2009年第13期|共8页
作者
Xu Bingsen; Huang Yingqun;
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正文语种 eng
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关键词
Animals; Cell Proliferation; Embryonic Stem Cells cy Cytology; Embryonic Stem Cells me Metabolism; Gene Expression Regulation; Histones ge Genetics; Histones me Metabolism; Mice; NIH 3T3 Cells; RNA; Messenger ch Chemistry; RNA; Messenger me Metabolism; RNA-Binding Proteins me Metabolism;

机译：动物;细胞增殖;胚胎干细胞cy [细胞学];胚胎干细胞me [代谢];基因表达调控;组蛋白ge [遗传学];组蛋白me [代谢];小鼠;NIH 3T3细胞;RNA;Messenger ch [化学];RNA;Messenger me [新陈代谢];RNA-Binding Proteins me [新陈代谢];

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专利

1. Histone H2a mRNA interacts with Lin28 and contains a Lin28-dependent posttranscriptional regulatory element. [J] . Xu Bingsen, Huang Yingqun Nucleic Acids Research . 2009,第13期

机译：组蛋白H2a mRNA与Lin28相互作用，并包含Lin28依赖性的转录后调控元件。
2. Identification of glyceraldehyde-3-phosphate dehydrogenase as a cellular protein that binds to the hepatitis B virus posttranscriptional regulatory element. [J] . Zang WQ, Fieno AM, Grant RA, Virology . 1998,第1期

机译：鉴定甘油三磷酸甘油脱氢酶是一种与乙型肝炎病毒转录后调控元件结合的细胞蛋白。
3. The stability and maturation of the H2A histone mRNAs from Trypanosoma cruzi are implicated in their post-transcriptional regulation. [J] . Maranon C, Thomas MC, Puerta C, Biochimica et biophysica acta: international journal of biochemistry and biophysics . 2000,第1a2期

机译：克氏锥虫H2A组蛋白mRNA的稳定性和成熟与它们的转录后调控有关。
4. Different reaction of the core histones H2A and H2B to red laser irradiation [C] . G.E. Brill, A.V. Egorova, I.O. Bugaeva, Optical Technologies in Biophysics Medicine . 2017

机译：核心组粒H2A和H2B对红色激光照射的不同反应
5. The HSV-1 regulatory protein ICP27 interacts with key host cell proteins to mediate the inhibition of pre-mRNA splicing and export of intronless viral mRNA. [D] . Sciabica, Kathryn Sullivan. 2001

机译：HSV-1调节蛋白ICP27与关键宿主细胞蛋白相互作用，以介导抑制前mRNA剪接和无内含子病毒mRNA的输出。
6. Histone H2a mRNA interacts with Lin28 and contains a Lin28-dependent posttranscriptional regulatory element [O] . Bingsen Xu, Yingqun Huang 2009

机译：组蛋白H2a mRNA与Lin28相互作用并包含Lin28依赖性转录后调控元件
7. Histone H2a mRNA interacts with Lin28 and contains a Lin28-dependent posttranscriptional regulatory element [O] . Xu, Bingsen, Huang, Yingqun 2009

机译：组蛋白H2a mRNA与Lin28相互作用并包含Lin28依赖性转录后调控元件

Histone H2a mRNA interacts with Lin28 and contains a Lin28-dependent posttranscriptional regulatory element.

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