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首页> 外文期刊>Nucleic Acids Research >Novel regulatory cascades controlling expression of nitrogen-fixation genes in Geobacter sulfurreducens
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Novel regulatory cascades controlling expression of nitrogen-fixation genes in Geobacter sulfurreducens

机译：新型调控级联反应控制固氮菌中还原固氮基因的表达

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摘要

Geobacter species often play an important role in bioremediation of environments contaminated with metals or organics and show promise for harvesting electricity from waste organic matter in microbial fuel cells. The ability of Geobacter species to fix atmospheric nitrogen is an important metabolic feature for these applications. We identified novel regulatory cascades controlling nitrogen-fixation gene expression in Geobacter sulfurreducens. Unlike the regulatory mechanisms known in other nitrogen-fixing microorganisms, nitrogen-fixation gene regulation in G. sulfurreducens is controlled by two two-component His-Asp phosphorelay systems. One of these systems appears to be the master regulatory system that activates transcription of the majority of nitrogen-fixation genes and represses a gene encoding glutamate dehydrogenase during nitrogen fixation. The other system whose expression is directly activated by the master regulatory system appears to control by antitermination the expression of a subset of the nitrogen-fixation genes whose transcription is activated by the master regulatory system and whose promoter contains transcription termination signals. This study provides a new paradigm for nitrogen-fixation gene regulation.
机译：地细菌菌种在对金属或有机物污染的环境进行生物修复中经常发挥重要作用，并有望从微生物燃料电池中的废弃有机物中收集电力。对于这些应用，地细菌物种固定大气氮的能力是重要的代谢特征。我们确定了新的调控级联控制固氮基因减少硫中的固氮基因表达。与其他固氮微生物中已知的调控机制不同，还原糖志贺菌中的固氮基因调控是由两个两组分的His-Asp磷酸酶系统控制的。这些系统之一似乎是主调节系统，该系统激活大多数固氮基因的转录并在固氮过程中抑制编码谷氨酸脱氢酶的基因。其表达被主调控系统直接激活的另一个系统似乎是通过抗终止来控制其固氮基因的子集的表达，所述固氮基因的转录被主调控系统激活并且其启动子包含转录终止信号。该研究为固氮基因调控提供了新的范例。

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