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首页> 外文期刊>Langmuir: The ACS Journal of Surfaces and Colloids >Microfluidic Fabrication of Monodisperse Polylactide Microcapsules with Tunable Structures through Rapid Precipitation Takaichi Watanabe,? Yukitaka Kimura,? and Tsutomu Ono*,? ?Department of Chemistry and Biotechnology, Graduate School of Natural Science and Technology and ?Department of Material and Energy Science, Graduate School of Environmental and Life Science, Okayama University, 3-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan
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Microfluidic Fabrication of Monodisperse Polylactide Microcapsules with Tunable Structures through Rapid Precipitation Takaichi Watanabe,? Yukitaka Kimura,? and Tsutomu Ono*,? ?Department of Chemistry and Biotechnology, Graduate School of Natural Science and Technology and ?Department of Material and Energy Science, Graduate School of Environmental and Life Science, Okayama University, 3-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan

机译：通过快速沉淀法微结构制备具有可调结构的单分散聚丙交酯微胶囊木村幸孝？还有小野勉（*）冈山大学北区对马中3-1-1冈山大学自然科学与技术研究生院化学与生物技术系和环境与生命科学研究生院材料与能源科学系700- 8530，日本

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摘要

We describe a versatile and facile route to the continuous production of monodisperse polylactide (PLA) microcapsules with controllable structures. With the combination of microfluidic emulsification, solvent diffusion, and internal phase separation, uniform PLA microcapsules with a perfluorooctyl bromide (PFOB) core were successfully obtained by simply diluting monodisperse ethyl acetate (EA)-in-water emulsion with pure water. Rapid extraction of EA from the droplets into the aqueous phase enabled the solidification of the polymer droplets in a nonequilibrium state during internal phase separation between a concentrated PLA/EA phase and a PFOB phase. Higher-molecular-weight PLA generated structural complexity of the microcapsules, yielding core?shell microcapsules with covered with small PFOB droplets. Removal of the PFOB via freeze drying gave hollow microcapsules with dimpled surfaces. The core?shell ratios and the diameter of these microcapsules could be finely tuned by just adjusting the concentration of PFOB and flow rates on emulsification, respectively. These biocompatible microcapsules with controllable size and structures are potentially applicable in biomedical fields such as drug delivery carriers of many functional molecules.
机译：我们描述了一种多用途且简便的方法，可连续生产具有可控结构的单分散聚丙交酯（PLA）微胶囊。通过将微流乳化，溶剂扩散和内部相分离相结合，仅用纯水稀释单分散的乙酸乙酯（EA）-水包水乳液即可成功获得具有全氟辛基溴化物（PFOB）核的均匀PLA微胶囊。将EA从液滴快速提取到水相中，可以在浓缩的PLA / EA相和PFOB相之间进行内相分离期间以非平衡状态固化聚合物液滴。较高分子量的PLA产生了微囊的结构复杂性，产生了核壳型微囊，其上覆盖着小的PFOB小滴。通过冷冻干燥除去PFOB，得到具有凹坑表面的中空微囊。通过分别调节PFOB的浓度和乳化时的流速，可以微调这些微胶囊的核壳比和直径。这些具有可控制的尺寸和结构的生物相容性微胶囊潜在地可应用于生物医学领域，例如许多功能分子的药物递送载体。

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