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首页> 外文期刊>Langmuir: The ACS Journal of Surfaces and Colloids >Surface properties and interaction forces of biopolymer-doped conductive polypyrrole surfaces by atomic force microscopy
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Surface properties and interaction forces of biopolymer-doped conductive polypyrrole surfaces by atomic force microscopy

机译：原子力显微镜观察生物聚合物掺杂的导电聚吡咯表面的表面性质和相互作用力

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摘要

Surface properties and electrical charges are critical factors elucidating cell interactions on biomaterial surfaces. The surface potential distribution and the nanoscopic and microscopic surface elasticity of organic polypyrrole-hyaluronic acid (PPy-HA) were studied by atomic force microscopy (AFM) in a fluid environment in order to explain the observed enhancement in the attachment of human adipose stem cells on positively charged PPy-HA films. The electrostatic force between the AFM tip and a charged PPy-HA surface, the tip-sample adhesion force, and elastic moduli were estimated from the AFM force curves, and the data were fitted to electrostatic double-layer and elastic contact models. The surface potential of the charged and dried PPy-HA films was assessed with Kelvin probe force microscopy (KPFM), and the KPFM data were correlated to the fluid AFM data. The surface charge distribution and elasticity were both found to correlate well with the nodular morphology of PPy-HA and to be sensitive to the electrochemical charging conditions. Furthermore, a significant change in the adhesion was detected when the surface was electrochemically charged positive. The results highlight the potential of positively charged PPy-HA as a coating material to enhance the stem cell response in tissue-engineering scaffolds.
机译：表面性质和电荷是阐明生物材料表面上细胞相互作用的关键因素。在流体环境中通过原子力显微镜（AFM）研究了有机聚吡咯-透明质酸（PPy-HA）的表面电势分布以及纳米和微观表面弹性，以解释观察到的人类脂肪干细胞附着的增强带正电的PPy-HA胶片上。根据AFM力曲线估算了AFM尖端和带电的PPy-HA表面之间的静电力，尖端样品的附着力和弹性模量，并将数据拟合到静电双层和弹性接触模型中。用开尔文探针力显微镜（KPFM）评估带电和干燥的PPy-HA膜的表面电势，并将KPFM数据与流体AFM数据相关。发现表面电荷分布和弹性均与PPy-HA的结节形态良好相关并且对电化学充电条件敏感。此外，当该表面被电化学带正电时，粘附力发生了显着变化。结果突出了带正电的PPy-HA作为涂层材料在增强组织工程支架中干细胞反应方面的潜力。

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