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首页> 外文期刊>Contemporary clinical trials >Factors associated with enrollment of African Americans into a clinical trial: results from the African American study of kidney disease and hypertension.
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Factors associated with enrollment of African Americans into a clinical trial: results from the African American study of kidney disease and hypertension.

机译：非裔美国人参加临床试验的相关因素：非裔美国人对肾脏疾病和高血压的研究结果。

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Recruitment of diverse populations into clinical trials remains challenging but is needed to fully understand disease processes and benefit the general public. Greater knowledge of key factors among ethnic and racial minority populations associated with the decision to participate in clinical research studies may facilitate recruitment and enhance the generalizibility of study results. Therefore, during the recruitment phase of the African American Study of Kidney Disease and Hypertension (AASK) trial, we conducted a telephone survey, using validated questions, to explore potential facilitators and barriers of research participation among eligible candidates residing in seven U.S. locations. Survey responses included a range of characteristics and perceptions among participants and non-participants and were compared using bivariate and step-wise logistic regression analyses. One-hundred forty-one respondents in the one-hundred forty (70 trial participants and 71 non-participants) completed the survey. Trial participants and non-participants were similar in multiple demographic characteristics and shared similar views on discrimination, physician mistrust, and research integrity. Key group differences were related to their perceptions of the impact of their research participation. Participants associated enrollment with personal and societal health benefits, while non-participants were influenced by the health risks. In a step-wise linear regression analysis, the most powerful significant positive predictors of participation were acknowledgement of health status as important in the enrollment decision (OR=4.54, p=0.006), employment (OR=3.12, p = 0.05) and healthcare satisfaction (OR=2.12, p<0.01). Racially-based mistrust did not emerge as a negative predictor and subjects' decisions were not influenced by the race of the research staff. In conclusion, these results suggest that health-related factors, and not psychosocial perceptions, have predominant influence on research participation among African Americans.
机译：在临床试验中招募不同人群仍然具有挑战性，但需要充分了解疾病过程并造福大众。决定参加临床研究相关的少数民族和少数族裔人口中的关键因素的更多知识可能会促进招聘并提高研究结果的可推广性。因此，在非裔美国人肾脏疾病和高血压研究（AASK）试验的招募阶段，我们使用经过验证的问题进行了电话调查，以探讨居住在美国七个地点的合格候选人中潜在的促进因素和研究参与的障碍。调查回应包括参与者和非参与者之间的一系列特征和看法，并使用双变量和逐步逻辑回归分析进行了比较。一百四十名中的一百四十一名受访者（70名试验参与者和71名非参与者）完成了调查。试验参与者和非参与者在多种人口统计学特征上相似，并且在歧视，医师不信任和研究完整性方面具有相似的观点。关键组差异与他们对研究参与影响的看法有关。参与者将入学与个人和社会健康利益相关联，而非参与者则受到健康风险的影响。在逐步线性回归分析中，参与的最有力的显着阳性预测因子是，健康状况的确认对入选决定（OR = 4.54，p = 0.006），就业（OR = 3.12，p = 0.05）和医疗保健至关重要满意度（OR = 2.12，p <0.01）。基于种族的不信任并没有成为负面的预测因素，并且受试者的决定不受研究人员种族的影响。总之，这些结果表明，与健康相关的因素而非心理社会观念对非裔美国人的研究参与具有主要影响。

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