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首页> 外文期刊>RSC Advances >Simultaneous colorimetric detection of four drugs in their pharmaceutical formulations using unmodified gold nanoparticles as a probe
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Simultaneous colorimetric detection of four drugs in their pharmaceutical formulations using unmodified gold nanoparticles as a probe

机译：使用未修饰的金纳米粒子作为探针同时比色检测其药物制剂中的四种药物

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摘要

We have developed a simple UV-visible spectrometric method for parallel detection of four drugs (venlafaxine, imipramine, amlodipine and alfuzosin) by using unmodified gold nanoparticles (Au NPs) as a colorimetric probe. The citrate was self-assembled onto the Au NPs to form a probe that undergoes a color change from red to blue by the addition of the four drugs. It is presumed that the color change is a result of the aggregation of the Au NPs induced by the four drugs, resulting a red-shift in their absorption spectra from 521 to 653, 695, 688 and 636 nm for venlafaxine, imipramine, amlodipine and alfuzosin, respectively. The method was validated in the concentration range of 0.001-100 mu M, where it demonstrated good linearity (R-2 = 0.997, 0.997, 0.995 and 0.998) with limits of detection in the range of 0.9-9.3 nM. The aggregation of the Au NPs induced by the four drugs was confirmed by dynamic light scattering (DLS) and transmission electron microscopy (TEM). The applicability of the method was demonstrated by determining the drugs contents in pharmaceutical and biological samples (urine and plasma).
机译：我们已经开发了一种简单的紫外线-可见光谱法，通过使用未修饰的金纳米颗粒（Au NPs）作为比色探针，可以并行检测四种药物（文拉法辛，丙咪嗪，氨氯地平和阿夫唑嗪）。将柠檬酸盐自组装到Au NP上以形成探针，通过添加四种药物，该探针的颜色从红色变为蓝色。据推测，颜色变化是四种药物诱导的金纳米颗粒聚集的结果，导致文拉法辛，丙咪嗪，氨氯地平和氨甲fa呤的吸收光谱从521nm移至653、695、688和636nm。阿夫唑嗪分别。该方法在0.001-100μM的浓度范围内得到验证，显示出良好的线性（R-2 = 0.997、0.997、0.995和0.998），检出限在0.9-9.3 nM之间。动态光散射（DLS）和透射电子显微镜（TEM）证实了这四种药物诱导的Au NP的聚集。通过测定药物和生物样品（尿液和血浆）中的药物含量证明了该方法的适用性。

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