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首页> 外文期刊>RSC Advances >Albumin stabilized gold nanostars: a biocompatible nanoplatform for SERS, CT imaging and photothermal therapy of cancer
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Albumin stabilized gold nanostars: a biocompatible nanoplatform for SERS, CT imaging and photothermal therapy of cancer

机译：白蛋白稳定的金纳米星：用于癌症的SERS，CT成像和光热疗法的生物相容性纳米平台

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摘要

Plasmonic nanoparticles have emerged as a multifunctional material for biomedical applications. In comparison to other nanostructures, plasmonic gold nanostars with their anisotropic geometry and photophysical properties have gained immense attention. However, their synthesis based on colloid chemistry has always relied on toxic reagents which raise huge concerns for their use in the body. Moreover, lack of stability and functional group for further bioconjugation limited their use. Herein, gold nanostars (GNS) were synthesized using a simple wet chemistry route without the use of any toxic reagents. These nanostars were further functionalized with albumin to impart stability yielding a monodispersed colloidal solution of particles with similar to 120 nm in size. The albumin stabilized gold nanostars (Alb-GNS) tagged with the Raman reporter dye, Rhodamine 6G exhibited a surface enhanced Raman scattering (SERS) property suggesting its potential use for Raman imaging. Alb-GNS exhibited extreme compatibility towards normal (L929) and cancerous (KB) cells with no reactive oxygen species development and hemolytic response towards red blood cells. Additionally, its superior computed tomographic (CT) contrast ability and photothermal activity towards cancer cells bring about Alb-GNS as a single platform for multimodal theragnostic application.
机译：等离子体等离子纳米颗粒已经成为一种用于生物医学应用的多功能材料。与其他纳米结构相比，具有各向异性几何形状和光物理性质的等离激元金纳米星受到了广泛关注。然而，它们基于胶体化学的合成一直依赖有毒试剂，这引起了它们在体内使用的巨大关注。而且，缺乏稳定性和用于进一步生物缀合的官能团限制了它们的使用。在本文中，使用简单的湿化学路线合成金纳米星（GNS），而不使用任何有毒试剂。将这些纳米星进一步用白蛋白官能化以赋予稳定性，从而得到粒径接近120 nm的颗粒的单分散胶体溶液。用拉曼报道染料若丹明6G标记的白蛋白稳定的金纳米星（Alb-GNS）表现出表面增强的拉曼散射（SERS）特性，表明其可用于拉曼成像。 Alb-GNS对正常（L929）和癌细胞（KB）表现出极强的相容性，没有活性氧的形成和对红细胞的溶血反应。此外，其优越的计算机断层扫描（CT）对比能力和对癌细胞的光热活性使Alb-GNS成为多峰疗法联合应用的单一平台。

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