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Nanoscale topography, semiconductor polarity and surface functionalization: additive and cooperative effects on PC12 cell behavior

机译：纳米级形貌，半导体极性和表面功能化：对PC12细胞行为的累加和协同作用

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摘要

This work compares the behavior of PC12 cells on planar and patterned III-nitride materials with nanostructured topographies. Three different materials' compositions containing N-polar and Ga-polar areas are studied: Al0.8Ga0.2N, Al0.7Ga0.3N, and GaN. Surface microscopy and spectroscopy, along with biological assays are used to understand the connection between nanoscopic features, polarity and surface functionalization. All materials are modified using a solution based approach to change their surface composition. The results demonstrate that altering the surface hydrophobicity can be used to generate additive effects with respect to protein adsorption in addition to the cooperative effects observed with respect to planes' polarity and topography. The work also details differences in the release of metal ions from clean and functionalized nanostructured III-polar and N-polar semiconductors in cell culture media, and their relationship to changes in cell response through quantification of cell viability and the production of reactive oxygen species. Our results demonstrate that nanoscale topography can be linked to additional parameters at the cell-semiconductor interface in order to understand and modulate PC12 cell behavior.
机译：这项工作比较了PC12电池在具有纳米结构形貌的平面和图案化III型氮化物材料上的行为。研究了包含N极和Ga极区域的三种不同材料的成分：Al0.8Ga0.2N，Al0.7Ga0.3N和GaN。表面显微镜和光谱学以及生物学测定法可用于了解纳米特征，极性和表面功能化之间的联系。使用基于解决方案的方法修改所有材料，以更改其表面成分。结果表明，改变表面疏水性可用于产生蛋白质吸附方面的附加作用，此外还可以观察到有关平面极性和形貌的协同作用。这项工作还详细介绍了细胞培养基中清洁和功能化的纳米结构III极性和N极性半导体中金属离子释放的差异，以及它们通过定量细胞活力和产生活性氧而与细胞反应变化之间的关系。我们的结果表明，纳米尺度的地形可以与细胞-半导体界面上的其他参数链接，以了解和调节PC12细胞的行为。

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