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首页> 外文期刊>RSC Advances >Environmentally sensitive nanohydrogels decorated with a three-strand oligonucleotide helix for controlled loading and prolonged release of intercalators
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Environmentally sensitive nanohydrogels decorated with a three-strand oligonucleotide helix for controlled loading and prolonged release of intercalators

机译：对环境敏感的纳米水凝胶，装饰有三链寡核苷酸螺旋，可控制负载并延长嵌入剂的释放

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Two different short DNA strands were attached to the surface of a gel nanoparticle. The third DNA strand that was 50 : 50 complementary to those strands allowed the formation of a three-strand hybrid. The gel nanoparticles were synthetized from N-isopropyloacrylamide (NIPA), N,N'-methylenebisacrylamide (BIS) and acrylic acid (AA) by employing the free radical polymerization reaction. The physicochemical parameters of this novel nanogel stimulated its penetration of selected cancer tissues (Hela and Insulinoma cells) and allowed effective delivery of the anticancer drug doxorubicin (Dox). Since the three-strand oligonucleotide hybrid sites were located at the surface of the nanogel, this allowed effective storing of Dox by its intercalation to the double stranded DNA. The binding through intercalation resulted in prolonged release of the drug. The release of Dox at selected temperatures was a consequence of oligo1-2-3 hybrid conformational change, the shrinking of the hydrogel and zeta-potential change.
机译：将两条不同的短DNA链连接到凝胶纳米颗粒的表面。与那些链互补的50:50的第三条DNA链允许形成三链杂交体。通过自由基聚合反应，由N-异丙基丙烯酰胺（NIPA），N，N'-亚甲基双丙烯酰胺（BIS）和丙烯酸（AA）合成凝胶纳米颗粒。这种新型纳米凝胶的物理化学参数刺激了其渗透到选定的癌组织（Hela和Insulinoma细胞），并允许有效递送抗癌药物阿霉素（Dox）。由于三链寡核苷酸杂合位点位于纳米凝胶的表面，因此可以通过将Dox插入双链DNA中来有效存储Dox。通过插入的结合导致药物的延长释放。 Dox在选定温度下的释放是oligo1-2-3杂合构象变化，水凝胶收缩和zeta电位变化的结果。

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