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首页> 外文期刊>RSC Advances >Phytosteroids and triterpenoids with potent cytotoxicities from the leaves of Chisocheton cumingianus
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Phytosteroids and triterpenoids with potent cytotoxicities from the leaves of Chisocheton cumingianus

机译：三角锥壳草叶片中具有强细胞毒性的植物类固醇和三萜类化合物

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摘要

Six phytosteroids and three dammarane-type triterpenoids, namely chisopanoids A-F (1-6) and chisopanones G-I (7-9), together with nine known triterpenoids (10-18) were isolated from the leaves of Chisocheton cumingianus. Their structures were elucidated by extensive spectroscopic analysis, X-ray crystallographic analysis, Mosher's method and Mo-2(OAc)(4)-induced electronic circular dichroism (ECD) data. All compounds were evaluated for their cytotoxicities against HepG2, U2OS and MCF-7 human cancer cell lines, as well as inhibitory effects on nitric oxide (NO) production in LPS-activated RAW 264.7 macrophages. Compounds 5 and 6 showed potent cytotoxicities towards MCF-7 with IC50 values of 3.24 +/- 1.39 and 8.85 +/- 4.73 mu M, and were further proved to inhibit the cell proliferation mainly by inducing apoptosis.
机译：从枯萎的Chisocheton cumingianus的叶子中分离出了六种类固醇和三种达玛烷类型的三萜类化合物，即chisopanoids A-F（1-6）和chisopanones G-1（7-9），以及九种已知的三萜类化合物（10-18）。通过广泛的光谱分析，X射线晶体分析，Mosher方法和Mo-2（OAc）（4）诱导的电子圆二色性（ECD）数据阐明了它们的结构。评估了所有化合物对HepG2，U2OS和MCF-7人类癌细胞系的细胞毒性，以及对LPS激活的RAW 264.7巨噬细胞中一氧化氮（NO）产生的抑制作用。化合物5和6显示出对MCF-7的强细胞毒性，IC 50值为3.24 +/- 1.39和8.85 +/-4.73μM，并且进一步被证明主要通过诱导细胞凋亡来抑制细胞增殖。

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