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首页> 外文期刊>RSC Advances >Interaction between dendrimers and regulatory proteins. Comparison of effects of carbosilane and carbosilane-viologen-phosphorus dendrimers
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Interaction between dendrimers and regulatory proteins. Comparison of effects of carbosilane and carbosilane-viologen-phosphorus dendrimers

机译：树状聚合物与调节蛋白之间的相互作用。碳硅烷和碳硅烷-紫精-磷树枝状聚合物的作用比较

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摘要

For nanoparticles to be used successfully in biomedical application, their interactions with biological fluids need to be investigated, in which they will react with proteins and other macromolecules. In this case, dendrimers might change their biological properties. Thus, the interaction of 2 generations of carbosilane-viologen-phosphorus and 2 types of carbosilane dendrimers with the 3 proteins - alkaline phosphatase from E. coli, human aspartate transaminase and l -lactate dehydrogenase from rabbit muscles, will be discussed. The techniques used included circular dichroism, zeta potential measurement, fluorescence quenching and transmission electron microscopy. The results show that positively charged hybrid and carbosilane dendrimers can interact with negatively charged regulatory proteins, and are able to form complexes. However, the spatial structure and the flexibility of dendrimer are as important as the protein configuration in complex formation.
机译：为了成功地将纳米粒子成功用于生物医学应用，需要研究其与生物流体的相互作用，其中它们将与蛋白质和其他大分子发生反应。在这种情况下，树枝状聚合物可能会改变其生物学特性。因此，将讨论2代碳硅烷-紫精-磷和2种碳硅烷树状大分子与3种蛋白质的相互作用-大肠杆菌的碱性磷酸酶，人天冬氨酸转氨酶和兔肌肉的l-乳酸脱氢酶。使用的技术包括圆二色性，ζ电势测量，荧光猝灭和透射电子显微镜。结果表明，带正电的杂化体和碳硅烷树状大分子可以与带负电的调节蛋白相互作用，并能够形成复合物。但是，树枝状大分子的空间结构和柔性与复合物形成中的蛋白质构型一样重要。

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