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首页> 外文期刊>RSC Advances >Mesenchymal stem cell (MSC) viability on PVA and PCL polymer coated hydroxyapatite scaffolds derived from cuttlefish
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Mesenchymal stem cell (MSC) viability on PVA and PCL polymer coated hydroxyapatite scaffolds derived from cuttlefish

机译：间充质干细胞（MSC）在来自乌贼的PVA和PCL聚合物包覆的羟基磷灰石支架上的生存力

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摘要

In the present study, cuttlefish bones are used to prepare highly porous hydroxyapatite (HA) scaffolds via hydrothermal treatment at 200 degrees C. Raw cuttlefish bones (CB) and the hydrothermal products have been analyzed and compared for their composition and microstructure, using X-ray powder diffraction (XRD), Optical Microscopy (OM), Scanning Electron Microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), porosity estimation and compressive strength measuring techniques. Characterization reveals that cuttlebone has high porosity approaching above 70%, and possesses the laminar structure of aragonite mixed with some organic materials. The compressive strength of the CB-HA is improved after coating with both polyvinyl alcohol (PVA) and polycaprolactone (PCL). Furthermore, our in vitro biocompatibility studies revealed that CB-HA and PVA coated CB-HA scaffolds are non-cytotoxic and support the adherence and proliferation of rMSCs, comparable to pure HA scaffolds. Altogether, our results suggest that naturally derived CB-HA, PVA and PCL coated CB-HA scaffolds are potential cheap candidates for bone tissue engineering applications, and also that PVA and PCL coatings provide better mechanical strength.
机译：在本研究中，乌贼骨用于通过200摄氏度的水热处理来制备高度多孔的羟基磷灰石（HA）支架。使用X-射线分析了墨乌贼骨（CB）和水热产物的成分和微观结构，并进行了比较。射线粉末衍射（XRD），光学显微镜（OM），扫描电子显微镜（SEM），傅立叶变换红外光谱（FTIR），孔隙率估算和抗压强度测量技术。表征表明，cut骨具有接近70％以上的高孔隙率，并且具有与一些有机材料混合的文石的层状结构。用聚乙烯醇（PVA）和聚己内酯（PCL）涂覆后，可改善CB-HA的抗压强度。此外，我们的体外生物相容性研究表明，与纯HA支架相比，CB-HA和PVA包被的CB-HA支架无细胞毒性，并支持rMSC的粘附和增殖。总而言之，我们的结果表明，天然来源的CB-HA，PVA和PCL涂层的CB-HA支架是骨组织工程应用的潜在廉价候选者，而且PVA和PCL涂层提供了更好的机械强度。

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