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首页> 外文期刊>RSC Advances >Preparation and characterization of interface-modified PLA/starch/PCL ternary blends using PLLA/triclosan antibacterial nanoparticles for medical applications
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Preparation and characterization of interface-modified PLA/starch/PCL ternary blends using PLLA/triclosan antibacterial nanoparticles for medical applications

机译：使用PLLA /三氯生抗菌纳米粒子的医学应用界面改性的PLA /淀粉/ PCL三元共混物的制备和表征

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In this study, the interface-modified ternary blends based on polylactic acid/starch/polycaprolactone were prepared via melt blending. On one hand, the addition of triclosan-loaded polylactic acid (LATC30) nanoparticles imparted antibacterial properties to the blend, and on the other hand, the interfacial affinity between hydrophilic starch and hydrophobic polyesters was improved by establishing interactions between -Cl groups of triclosan and ester groups of PCL. AFM and rheological results demonstrated that the starch particles are very coarse in PLA/starch 50:50 (PLAS50) but as the content of PCL increased, the extent of chemical interactions between starch and PCL was increased which resulted in a much better dispersion and homogeneity of starch within the ternary blends. Tensile analysis indicated that the interface modification of starch by the hydrophobic PCL and triclosan significantly improved the elongation at break and tensile strength values of PLAS50, and the mechanical character of blends was transformed from brittle to ductile. Biodegradability was also investigated and the triclosan release rate was tuned, while the blends are also antibacterial and their cell-viability was approved. Overall, the ternary blending approach of PLA/starch/PCL using triclosan is a promising technique to extend the property range of PLA suitable for many medical applications.
机译：在这项研究中，通过熔融共混制备了基于聚乳酸/淀粉/聚己内酯的界面改性三元共混物。一方面，添加三氯生负载的聚乳酸（LATC30）纳米颗粒可赋予共混物抗菌性能，另一方面，通过在三氯生的-Cl基团和三氯生之间建立相互作用，可以改善亲水性淀粉与疏水性聚酯之间的界面亲和力。 PCL的酯基。 AFM和流变学结果表明，在PLA /淀粉50:50（PLAS50）中，淀粉颗粒非常粗大，但随着PCL含量的增加，淀粉与PCL之间的化学相互作用的程度也增加，这导致更好的分散性和均匀性三元混合物中的淀粉含量。拉伸分析表明，疏水性PCL和三氯生对淀粉的界面改性显着提高了PLAS50的断裂伸长率和拉伸强度值，共混物的机械性能从脆性转变为韧性。还研究了生物降解性，并调节了三氯生的释放速率，而共混物也具有抗菌性，并且其细胞生存能力得到认可。总体而言，使用三氯生的PLA /淀粉/ PCL三元共混方法是一种有前途的技术，可以扩展PLA的性能范围，适用于许多医疗应用。

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