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首页> 外文期刊>RSC Advances >Doxorubicin-loaded ionic liquid-polydopamine nanoparticles for combined chemotherapy and microwave thermal therapy of cancer
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Doxorubicin-loaded ionic liquid-polydopamine nanoparticles for combined chemotherapy and microwave thermal therapy of cancer

机译：载有阿霉素的离子液体-聚多巴胺纳米颗粒，用于癌症的化学疗法和微波热疗相结合

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摘要

Recently, combinational therapy has been increasingly employed in the treatment of cancer. In this study, hollow polydopamine nanoparticles were developed as favorable biocompatible delivery nanoplatforms for chemotherapy and microwave thermal therapy. By loading polydopamine nanoparticles with ionic liquid, the functionalized polydopamine nanoparticles became chemotherapeutic drug nanocarriers for combinational therapy. The obvious antitumor efficacy of doxorubicin-loaded ionic liquid-polydopamine nanocomposites was demonstrated in in vitro and in vivo experiments for combined chemotherapy and microwave thermal therapy. Moreover, the combination of chemotherapy with microwave thermal therapy applied to cancer therapy based on drug-loaded ionic liquid-polydopamine nanocomposites is a promising therapy for future cancer treatment in clinical applications.
机译：近来，组合疗法已经越来越多地用于癌症的治疗中。在这项研究中，中空的聚多巴胺纳米颗粒被开发为用于化学疗法和微波热疗法的有利的生物相容性传递纳米平台。通过用离子液体装载聚多巴胺纳米颗粒，官能化的聚多巴胺纳米颗粒成为用于联合治疗的化学治疗药物纳米载体。结合阿霉素的离子液体-聚多巴胺纳米复合物的体外和体内实验证明了联合化疗和微波热疗法的明显抗肿瘤功效。此外，基于载药的离子液体-聚多巴胺纳米复合材料的化学疗法与微波热疗法相结合的癌症疗法是一种有前途的疗法，可用于未来临床上的癌症治疗。

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