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首页> 外文期刊>RSC Advances >Potential of a novel peptide P16-D from the membrane-proximal external region of human immunodeficiency virus type 1 to enhance retrovirus infection
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Potential of a novel peptide P16-D from the membrane-proximal external region of human immunodeficiency virus type 1 to enhance retrovirus infection

机译：来自人类免疫缺陷病毒1型膜近端外部区域的新型肽P16-D增强逆转录病毒感染的潜力

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摘要

The peptide P13 (Ac-(NWFDITNWLWYIK683)-N-671-NH2), derived from the membrane-proximal external region (MPER) of the human immunodeficiency virus type 1 (HIV-1) transmembrane protein and its derivative P16, have been shown to significantly boost HIV-1 infectivity by forming amyloid fibrils. Here, a new modified nanofibril peptide P16-D derived from P16 was demonstrated to have an enhanced ability to promote retroviral gene transfer. Moreover, the "networks" formed by P16-D nanofibrils could effectively capture and concentrate enveloped virus by low-speed centrifugation. In addition, the captured influenza virus H1N1 could elicit a stronger immune response in mice at a lower dose than that in the absence of the nanofibrils. The results implied a potential for P16-D to improve gene transfer rates and vaccine applications.
机译：肽P13（Ac-（NWFDITNWLWYIK683）-N-671-NH2）来源于人免疫缺陷病毒1型（HIV-1）跨膜蛋白的近膜外部区域（MPER）及其衍生物P16通过形成淀粉样蛋白原纤维来显着提高HIV-1的感染力。在此，从P16衍生的新的修饰的纳米原纤维肽P16-D被证明具有增强的逆转录病毒基因转移能力。此外，由P16-D纳米原纤维形成的“网络”可以通过低速离心有效捕获和浓缩包膜病毒。此外，与没有纳米原纤维的情况相比，捕获的流感病毒H1N1可以在小鼠中以更低的剂量引发更强的免疫反应。该结果表明P16-D具有改善基因转移率和疫苗应用的潜力。

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