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Nuclear architecture and gene silencing in olfactory sensory neurons

机译:嗅觉感觉神经元的核结构和基因沉默

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摘要

Odorants are discriminated by hundreds of odorant receptor (OR) genes, which are dispersed throughout the mammalian genome. The OR genes are expressed in a highly specialized type of cell, the olfactory sensory neuron. Each one of these neurons expresses one of the 2 alleles from one single OR gene type. The mechanisms underlying OR gene expression are unclear. Here we describe recent work demonstrating that the olfactory sensory neuron shows a particular nuclear architecture, and that the genomic ORloci are colocalized in silencing heterochromatin compartments within the nucleus. These discoveries highlight the important role played by epigenetic modifications and nuclear genome organization in the regulation of OR gene expression.
机译:气味由数百个气味受体(OR)基因区分,这些基因分散在整个哺乳动物基因组中。 OR基因在高度专业化的细胞(嗅觉感觉神经元)中表达。这些神经元中的每一个都表达来自一种单一OR基因类型的2个等位基因之一。 OR基因表达的潜在机制尚不清楚。在这里,我们描述了最近的工作,这些工作表明嗅觉感觉神经元显示出特定的核结构,并且基因组ORloci共定位在沉默核内的异染色质区室中。这些发现凸显了表观遗传修饰和核基因组组织在调节OR基因表达中所起的重要作用。

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