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首页> 外文期刊>BioArchitecture >Tropomodulin3 as the link between insulin-activated AKT2and cortical actin remodeling in preparation of GLUT4 exocytosis
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Tropomodulin3 as the link between insulin-activated AKT2and cortical actin remodeling in preparation of GLUT4 exocytosis

机译：Tropomodulin3作为胰岛素激活的AKT2与皮质肌动蛋白重塑之间的联系，以制备GLUT4胞吐作用

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It is well established that insulin-induced remodeling of actin filaments into a cortical mesh is required for insulin-stimulated GLUT4 exocytosis. Akt2 and its downstream effectors play a pivotal role in mediating the translocation and membrane fusion of GLUT4-storage vesicle (GSV). However, the direct downstream effector underlying the event of cortical actin reorganization has not been elucidated. In a recent study in Nature Communications,1 Lim et al identify Tropomodulin3 (Tmod3) as a downstreamtarget of the Akt2 kinase and describe the role of this pointed-end actin-capping protein in regulating insulin-dependent exocytosis of GSVs in adipocytes through the remodeling of the cortical actin network. Phosphorylation of Tmod3 by Akt2 on Ser71 modulates insulin-induced actin remodeling, a key step for GSV fusion with the plasma membrane (PM). Furthermore, the authors establish Tm5NMl (Tpm3.1 in new nomenclature)2 as the cognate tropomyosin partner of Tmod3, and an essential role of Tmod3-Tm5NMlinteraction for GSV exocytosis and glucose uptake. This study elucidates a novel effector of Akt2 that provides a direct mechanistic link between Akt2 signaling and actin reorganization essential for vesicle fusion, and suggests that a subset of actin filaments with specific molecular compositions may be dedicated for the process of vesicle fusion.
机译：众所周知，胰岛素刺激的GLUT4胞吐作用需要胰岛素诱导的肌动蛋白丝重塑成皮层网。 Akt2及其下游效应物在介导GLUT4存储小泡（GSV）的易位和膜融合中起关键作用。然而，尚未阐明皮质肌动蛋白重组事件背后的直接下游效应子。在Nature Communications的一项最新研究中，1 Lim等人将Tropomodulin3（Tmod3）鉴定为Akt2激酶的下游靶标，并描述了这种尖端肌动蛋白封端蛋白在通过重塑调节脂肪细胞中GSV的胰岛素依赖性胞吐作用中的作用皮质肌动蛋白网络。 Tkt3在Ser71上被Akt2磷酸化，从而调节胰岛素诱导的肌动蛋白重塑，这是GSV与质膜（PM）融合的关键步骤。此外，作者建立了Tm5NM1（新命名法中的Tpm3.1）2作为Tmod3的同源原肌球蛋白伴侣，以及Tmod3-Tm5NM相互作用对GSV胞吐作用和葡萄糖摄取的重要作用。这项研究阐明了一种新型的Akt2效应子，该效应子在Akt2信号传导和囊泡融合所必需的肌动蛋白重组之间提供了直接的机械联系，并暗示具有特定分子组成的肌动蛋白丝的子集可能专门用于囊泡融合的过程。

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