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Stabilization of neuronal connections and the axonal cytoskeleton

机译：稳定神经元连接和轴突细胞骨架

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Stabilization of axonal connections is an underappreciated, but critical, element in development and maintenance of neuronal functions. The ability to maintain the overall architecture of the brain for decades is essential for our ability to process sensory information efficiently, coordinate motor activity, and retain memories for a lifetime. While the importance of the neuronal cyto-skeleton in this process is acknowledged, little has been known about specializations of the axonal cytoskeleton needed to stabilize neuronal architectures. A novel post-translational modification of tubulin that stabilizes normally dynamic microtubules in axons has now been identified. Polyamination appears to be enriched in axons and is developmentally regulated witha time course that correlates with increased microtubule stabilization. Identifying one of the molecular mechanisms for maintaining neuronal connections creates new research avenues for understanding the role of stabilizing neuronal architecture in neuronal function and in neuropathology.
机译：轴突连接的稳定是神经元功能发展和维持中的一个未被充分认识的关键因素。数十年来保持大脑整体结构的能力对于我们有效处理感官信息，协调运动活动并保留一生的记忆至关重要。尽管人们已经认识到神经元细胞骨架在此过程中的重要性，但对于稳定神经元结构所需的轴突细胞骨架的专业化知之甚少。现已鉴定出微管蛋白的新型翻译后修饰，可稳定轴突中通常动态的微管。多胺化似乎富含轴突，并且通过与增加的微管稳定性相关的时间过程进行发育调节。确定维持神经元连接的分子机制之一，为了解稳定神经元结构在神经元功能和神经病理学中的作用创造了新的研究途径。

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