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首页> 外文期刊>BioArchitecture >Composite biopolymer scaffolds shape muscle nucleus: Insights and perspectives from Drosophila
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Composite biopolymer scaffolds shape muscle nucleus: Insights and perspectives from Drosophila

机译：复合生物聚合物支架塑造肌肉核：果蝇的见解和观点。

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摘要

Contractile muscle fibers produce enormous intrinsic forces during contraction/relaxation waves. These forces are directly applied to their cytoplasmic organelles including mitochondria, sarcoplasmic reticulum, and multiple nuclei. Data from our analysis of Drosophila larval somatic muscle fibers suggest that an intricate network of organized microtubules (MT) intermingled with Spectrin-Repeat-Containing Proteins (SRCPs) are major structural elements that protect muscle organelles and maintain theirstructure and position during muscle contraction. Whereas the perinuclear MT network provides structural rigidity to the myonucleus, the SRCPs Nesprin and Spectraplakin form semiflexible filamentous biopolymer networks, providing nuclei with the elasticity required to resist the contractile cytoplasmic forces produced by the muscle. Spectrin repeats are domains found in numerous structural proteins, which are able to unfold under tension and are subject to mechanical stresses in the cell. This unique composite scaffold combines rigidity and resilience in order to neutralize the oscillating cellular forces occurring during muscle contraction/ relaxation waves and thereby protect myonuclei. We suggest that the elastic properties of SRCPs are critical fornuclear protection and proper function in muscle fibers.
机译：收缩肌纤维在收缩/松弛波中产生巨大的内在力。这些力直接作用于其细胞质细胞器，包括线粒体，肌质网和多核。我们对果蝇幼虫体肌纤维的分析数据表明，复杂的有组织微管（MT）网络与含Spectrin重复蛋白（SRCP）混杂在一起，是保护肌肉细胞器并在肌肉收缩期间保持其结构和位置的主要结构要素。核周MT网络为肌核提供结构刚性，而SRCP Nesprin和Spectraplakin形成半柔性的丝状生物聚合物网络，为核提供了抵抗肌肉产生的收缩细胞质力所需的弹性。血影蛋白重复序列​​是在许多结构蛋白中发现的结构域，这些结构蛋白能够在张力下展开并在细胞中受到机械应力。这种独特的复合支架结合了刚度和回弹力，以抵消肌肉收缩/松弛波期间发生的振荡细胞力，从而保护肌核。我们建议，SRCPs的弹性特性对于保护肌肉和在肌肉纤维中发挥适当功能至关重要。

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