Optically absorbing nanoparticle mediated cell membrane permeabilization

Kiran Bhattacharyya; Smit Mehta; John Viator

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Optically absorbing nanoparticle mediated cell membrane permeabilization

机译：光学吸收纳米粒子介导的细胞膜通透性

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Membrane permeabilization is imperative for gene and drug delivery systems, along with other cell manipulation methods, since the average eukaryotic cell membrane is not permeable to polar and large nonpolar molecules. Antibody conjugated optically absorbing gold nanospheres are targeted to the cell membrane of T47D breast cancer cell line and irradiated with 5 ns pulse, 20 Hz, 532 nm light to increase membrane permeability. Up to 90% permeabilization with less than 6% death is reported at radiant exposures up to 10 times lower than those of other comparable studies.

机译：膜通透性对于基因和药物传递系统以及其他细胞操作方法至关重要，因为普通的真核细胞膜不能渗透极性和较大的非极性分子。抗体偶联的光学吸收金纳米球靶向T47D乳腺癌细胞系的细胞膜，并用5 ns脉冲，20 Hz，532 nm的光照射以增加膜的通透性。据报道，在辐射照射下，高达90％的通透性和少于6％的死亡是其他同类研究的10倍。

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《Optics Letters》 |2012年第21期|共3页
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Kiran Bhattacharyya; Smit Mehta; John Viator;
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1. Optically absorbing nanoparticle mediated cell membrane permeabilization [J] . Kiran Bhattacharyya, Smit Mehta, John Viator Optics Letters . 2012,第21期

机译：光学吸收纳米粒子介导的细胞膜通透性
2. Cellular entry of nanoparticles via serum sensitive clathrin-mediated endocytosis, and plasma membrane permeabilization [Corrigendum] [J] . Corrigendum International Journal of Nanomedicine . 2015,第1期

机译：纳米粒子通过血清敏感性网格蛋白介导的内吞作用进入细胞，并质膜通透[Corrrendum]
3. Cellular entry of nanoparticles via serum sensitive clathrin-mediated endocytosis, and plasma membrane permeabilization [J] . Philip J Smith, Maude Giroud, Helen L Wiggins, International Journal of Nanomedicine . 2012,第2期

机译：通过血清敏感网格蛋白介导的内吞作用和质膜通透性使纳米颗粒进入细胞
4. Enhancement of the Cytotoxic Effects of Bleomycin with Permeabilization of the Plasma Membrane by Photofrin~R-Mediated Photodynamic Therapy In Vitro [C] . Daisuke Nishikiori, Yuichi Miyamoto International Conference on Biomedical Engineering . 2014

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5. Biochips employing microelectrodes and microtransducers for characterization and permeabilization of cell membrane at the whole-cell and cellular level. [D] . Thein, Myo Min. 2010

机译：生物芯片采用微电极和微换能器在全细胞和细胞水平上表征和透化细胞膜。
6. Cellular entry of nanoparticles via serum sensitive clathrin-mediated endocytosis and plasma membrane permeabilization Corrigendum [O] . 2015

机译：纳米颗粒通过血清敏感的网格蛋白介导的内吞作用进入细胞并质膜通透Corrrendum
7. Cellular entry of nanoparticles via serum sensitive clathrin-mediated endocytosis, and plasma membrane permeabilization Corrigendum [O] . Joshua Rappoport 2015

机译：纳米颗粒通过血清敏感克拉棘介导的内吞作用的细胞进入，并血浆膜透露性逆静脉

Optically absorbing nanoparticle mediated cell membrane permeabilization

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