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首页> 外文期刊>Optics Letters >Colocalization of gold nanoparticle-conjugated DNA hybridization for enhanced surface plasmon detection using nanograting antennas
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Colocalization of gold nanoparticle-conjugated DNA hybridization for enhanced surface plasmon detection using nanograting antennas

机译：金纳米粒子-共轭DNA杂交的共定位，用于使用纳米光栅天线增强表面等离子体检测。

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摘要

We have investigated enhanced surface plasmon resonance detection through colocalization of gold nanoparticle (GNP)-conjugated target molecules and near-fields established by nanograting-based antennas. The target colocalization was implemented by angled dielectric thin-film deposition on the nanograting structure. The concept was tested by detecting DNA hybridization and shows that the colocalization produces an additional 60percent-80percent increase of resonance shifts. The colocalization involves a much smaller number of target molecules, so that the measured enhancement per molecule by the colocalization of GNP-conjugated DNA oligomers was estimated to be by more than 2 orders of magnitude relative to that of thin-film-based conventional detection.
机译：我们已经研究了共轭金纳米粒子（GNP）结合的目标分子和基于纳米光栅的天线建立的近场的增强的表面等离子体共振检测。通过在纳米光栅结构上成角度的介电薄膜沉积来实现目标共定位。该概念通过检测DNA杂交进行了测试，结果表明共定位可产生60％-80％的额外共振位移增加。共定位涉及的靶分子数量要少得多，因此相对于基于薄膜的常规检测方法，与共轭GNP的DNA低聚物共定位所测得的每个分子的增强作用估计超过2个数量级。

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