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Diagnostic value of nonlinear optical signals from collagen matrix in the detection of epithelial precancer

机译：胶原基质中非线性光学信号在上皮癌前病变中的诊断价值

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During precancer development in epithelium, neoplastic cells remodel the underlying stroma, for example, the basement membrane, capillaries, fibroblasts, and extracellular matrix. The purpose of this study is to investigate the relationship between the nonlinear optical signals from the collagen matrix in stroma and the progression of early epithelial carcinogenesis. Two-photon excited fluorescence (TPEF) and second harmonic generation (SHG) signals were measured from the stroma of hamster oral cheek pouch in vivo. We found that three features, including the intensity ratio of TPEF over SHG, the spatial frequency distribution, and the texture feature of SHG images, provide the quantitative identification of epithelial precancer at different pathologic stages. We demonstrated that the combination of all three features by using a support vector machine algorithm can significantly improve the accuracy in the detection of epithelial precancer.
机译：在上皮癌变前的发展过程中，肿瘤细胞会重塑基础间质，例如基底膜，毛细血管，成纤维细胞和细胞外基质。这项研究的目的是调查基质中胶原基质的非线性光学信号与早期上皮癌变进展之间的关系。从体内仓鼠口腔颊袋的基质中测量了双光子激发荧光（TPEF）和二次谐波产生（SHG）信号。我们发现，TPEF相对于SHG的强度比，空间频率分布以及SHG图像的纹理特征这三个特征可提供不同病理阶段上皮癌前病变的定量鉴定。我们证明了通过使用支持向量机算法将所有三个功能结合在一起可以显着提高上皮癌前病变的检测准确性。

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