Fast synchronized dual-wavelength laser speckle imaging system for monitoring hemodynamic changes in a stroke mouse model

Jia Qin; Lei Shi; Suzan Dziennis; Roberto Reif; Ruikang K. Wang

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Fast synchronized dual-wavelength laser speckle imaging system for monitoring hemodynamic changes in a stroke mouse model

机译：快速同步双波长激光散斑成像系统，用于监测中风小鼠模型中的血流动力学变化

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In this Letter, we describe a newly developed synchronized dual-wavelength laser speckle contrast imaging system, which contains two cameras that are synchronously triggered to acquire data. The system can acquire data at a high spatiotemporal resolution (up to 500 Hz for ～1000 × 1000 pixels). A mouse model of stroke is used to demonstrate the capability for imaging the fast changes (within tens of milliseconds) in oxygenated and deoxygenated hemoglobin concentration, and the relative changes in blood flow in the mouse brain, through an intact cranium. This novel imaging technology will enable the study of fast hemodynamics and metabolic changes in vascular diseases.

机译：在这封信中，我们描述了一个新开发的同步双波长激光散斑对比度成像系统，其中包含两个被同步触发以获取数据的相机。该系统可以以高时空分辨率（〜1000×1000像素高达500 Hz）采集数据。使用中风的小鼠模型演示了通过完整的颅骨对氧化和脱氧血红蛋白浓度的快速变化（数十毫秒内）以及鼠标脑中血流的相对变化进行成像的能力。这项新颖的成像技术将使研究血管疾病的快速血液动力学和代谢变化成为可能。

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《Optics Letters》 |2012年第19期|共3页
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Jia Qin; Lei Shi; Suzan Dziennis; Roberto Reif; Ruikang K. Wang;
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1. Fast synchronized dual-wavelength laser speckle imaging system for monitoring hemodynamic changes in a stroke mouse model [J] . Jia Qin, Lei Shi, Suzan Dziennis, Optics Letters . 2012,第19期

机译：快速同步双波长激光散斑成像系统，用于监测中风小鼠模型中的血流动力学变化
2. Hemodynamic and morphological vasculature response to a burn monitored using a combined dual-wavelength laser speckle and optical microangiography imaging system [J] . Jia Qin, Roberto Reif, Zhongwei Zhi, Biomedical Optics Express . 2012,第3期

机译：使用双波长激光散斑和光学微血管造影成像系统监测的对烧伤的血流动力学和形态血管反应
3. Hemodynamic effects of intraoperative anesthetics administration in photothrombotic stroke model: a study using laser speckle imaging [J] . Hongyang Lu, Yao Li, Bin Bo, BMC Neuroscience . 2017,第1期

机译：术中麻醉剂在光血栓形成性卒中模型中的血流动力学影响：使用激光散斑成像的研究
4. Flexibly combined optical microangiography and dual-wavelength laser speckle system for comprehensive imaging of hemodynamic and metabolic responses [C] . Lei Shi, Jia Qin, Lin An, Optical Coherence tomography and coherence domain optical methods in biomedicine XVIII . 2014

机译：灵活组合的光学微血管造影术和双波长激光散斑系统，可对血流动力学和代谢反应进行全面成像
5. Application of Vertical-Cavity Surface-Emitting Lasers for Simultaneous Laser Speckle Contrast and Intrinsic Optical Signal Imaging: Toward Chronic Portable Cortical Hemodynamic Imaging. [D] . Ringuette, Dene. 2012

机译：垂直腔面发射激光器在同时进行激光散斑对比度和内在光信号成像中的应用：走向慢性便携式皮层血流动力学成像。
6. Fast synchronized dual-wavelength laser speckle imaging system for monitoring hemodynamic changes in a stroke mouse model [O] . Jia Qin, Lei Shi, Suzan Dziennis, -1

机译：快速同步的双波长激光散斑成像系统用于在行程小鼠模型中监测血流动力学变化
7. Hemodynamic and morphological vasculature response to a burn monitored using a combined dual-wavelength laser speckle and optical microangiography imaging system [O] . Qin, Jia, Reif, Roberto, Zhi, Zhongwei, 2012

机译：使用双波长激光散斑和光学微血管造影成像系统监测的对烧伤的血流动力学和形态血管反应

Fast synchronized dual-wavelength laser speckle imaging system for monitoring hemodynamic changes in a stroke mouse model

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