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首页> 外文期刊>Optics Letters >Thermal and optical characterization of micro-LED probes for in vivo optogenetic neural stimulation
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Thermal and optical characterization of micro-LED probes for in vivo optogenetic neural stimulation

机译：用于体内光遗传神经刺激的micro-LED探针的热和光学表征

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Within optogenetics there is a need for compact light sources that are capable of delivering light with excellent spatial, temporal, and spectral resolution to deep brain structures. Here, we demonstrate a custom GaN-based LED probe for such applications and the electrical, optical, and thermal properties are analyzed. The output power density and emission spectrum were found to be suitable for stimulating channelrhodopsin-2, one of the most common light-sensitive proteins currently used in optogenetics. The LED device produced high light intensities, far in excess of those required to stimulate the light-sensitive proteins within the neurons. Thermal performance was also investigated, illustrating that a broad range of operating regimes in pulsed mode are accessible while keeping a minimum increase in temperature for the brain (0.5℃). This type of custom device represents a significant step forward for the optogenetics community, allowing multiple bright excitation sites along the length of a minimally invasive neural probe.
机译：在光遗传学内，需要一种紧凑的光源，该光源能够将具有出色的空间，时间和光谱分辨率的光传输到深层大脑结构。在这里，我们演示了针对此类应用的定制GaN基LED探针，并对电，光学和热性能进行了分析。发现输出功率密度和发射光谱适合刺激Channelrhodopsin-2，它是目前光遗传学中最常用的感光蛋白之一。 LED装置产生高的光强度，远远超过了刺激神经元内的光敏蛋白所需的光强度。还对热性能进行了研究，结果表明，在保持最低温度（0.5摄氏度）的情况下，可以使用多种脉冲模式的运行方式。这种类型的定制设备代表了光遗传学界的一个重大进步，它允许沿着微创神经探针的长度方向出现多个明亮的激发位点。

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