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首页> 外文期刊>Optics Letters >Breathing laser as an inertia-free swept source for high-quality ultrafast optical bioimaging
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Breathing laser as an inertia-free swept source for high-quality ultrafast optical bioimaging

机译:呼吸激光器作为无惯性扫掠光源,用于高质量超快光学生物成像

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摘要

We demonstrate an all-fiber breathing laser as inertia-free swept source (BLISS), with an ultra-compact design, for the emerging ultrafast bioimaging modalities. The unique feature of BLISS is its broadband wavelength-swept operation (similar to 60 nm) with superior temporal stability in terms of both long term (0.08 dB over 27 h) and shot-to-shot power variations (2.1%). More importantly, it enables a wavelength sweep rate of > 10 MHz (similar to 7 x 10(8) nm/s)-orders of- magnitude faster than the existing swept sources based on mechanical or electrical tuning techniques. BLISS thus represents a practical and new generation of swept source operating in the unmet megahertz swept-rate regime that aligns with the pressing need for scaling the optical bioimaging speed in ultrafast phenomena study or high-throughput screening applications. To showcase its utility in high-speed optical bioimaging, we here employ BLISS for ultrafast time-stretch microscopy and multi-MHz optical coherence tomography of the biological specimen at a single-shot line-scan rate or A-scan rate of 11.5 MHz. (C) 2014 Optical Society of America
机译:我们展示了一种超紧凑设计的全光纤呼吸激光器作为无惯性扫频光源(BLISS),用于新兴的超快生物成像模式。 BLISS的独特之处在于其宽带波长扫描操作(类似于60 nm),在长期(27小时内为0.08 dB)和逐次功率变化(2.1%)方面具有卓越的时间稳定性。更重要的是,与基于机械或电子调谐技术的现有扫频光源相比,它可以使波长扫描速率> 10 MHz(类似于7 x 10(8)nm / s)数量级。因此,BLISS代表了一种实用的新一代扫频光源,它以未满足的兆赫兹扫频速率工作,与在超快现象研究或高通量筛选应用中缩放光学生物成像速度的迫切需求相吻合。为了展示其在高速光学生物成像中的实用性,我们在这里采用BLISS进行生物样品的超快时间拉伸显微镜和多MHz光学相干断层扫描,其单次线扫描速率或11.5 MHz的A扫描速率。 (C)2014年美国眼镜学会

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