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首页> 外文期刊>Optics Letters >Simultaneous optical coherence tomography angiography and fluorescein angiography in rodents with normal retina and laser-induced choroidal neovascularization
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Simultaneous optical coherence tomography angiography and fluorescein angiography in rodents with normal retina and laser-induced choroidal neovascularization

机译：视网膜正常和激光诱导的脉络膜新生血管形成的啮齿动物同时进行光学相干断层扫描血管造影和荧光素血管造影

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摘要

Fluorescein angiography (FA) is the current clinical imaging standard for vascular related retinal diseases such as macular degeneration and diabetic retinopathy. However, FA is considered invasive and can provide only two-dimensional imaging. In comparison, optical coherence tomography angiography (OCTA) is noninvasive and can generate three-dimensional imaging; investigations of OCTA already demonstrated great promise in retinal vascular imaging. Yet, to further develop and apply OCTA, strengths and weaknesses between OCTA and FA need to be thoroughly compared. To avoid complications in image registration, an ideal comparison requires co-registered and simultaneous imaging by both FA and OCTA. In this Letter, we developed a system with integrated laser-scanning ophthalmoscope FA (SLO-FA) and OCTA, and conducted simultaneous dual-modality retinal vascular imaging in rodents. In imaging healthy rodent eyes, OCTA can resolve retinal capillaries better than SLO-FA does, particularly deep capillaries. In imaging rodent eyes with laser-induced choroidal neovascularization (CNV), OCTA can identify CNV that eludes SLO-FA detection. (C) 2015 Optical Society of America
机译：荧光素血管造影术（FA）是当前与血管相关的视网膜疾病（如黄斑变性和糖尿病性视网膜病）的临床成像标准。但是，FA被认为是侵入性的，只能提供二维成像。相比之下，光学相干断层扫描血管造影（OCTA）是无创的，可以生成三维成像。 OCTA的研究已经显示出在视网膜血管成像中的巨大前景。但是，要进一步开发和应用OCTA，需要将OCTA和FA之间的优缺点进行彻底比较。为了避免图像配准的复杂性，理想的比较需要FA和OCTA共同配准和同时成像。在这封信中，我们开发了集成了激光扫描检眼镜FA（SLO-FA）和OCTA的系统，并在啮齿动物中同时进行了双模态视网膜血管成像。在对啮齿动物的眼睛进行健康成像时，OCTA可以比SLO-FA更好地分辨视网膜毛细血管，特别是深毛细血管。在用激光诱发的脉络膜新生血管（CNV）对啮齿动物的眼睛进行成像时，OCTA可以识别出无法进行SLO-FA检测的CNV。 （C）2015年美国眼镜学会

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