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首页> 外文期刊>Optics Letters >Development of a hybrid Raman spectroscopy and optical coherence tomography technique for real-time in vivo tissue measurements
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Development of a hybrid Raman spectroscopy and optical coherence tomography technique for real-time in vivo tissue measurements

机译：开发用于实时体内组织测量的混合拉曼光谱和光学相干断层扫描技术

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We report on the development of a unique sideview hand-held hybrid Raman spectroscopy (RS) and optical coherence tomography (OCT) technique for real-time in vivo tissue measurements. A sideview handheld RS-OCT optical probe is designed to coalign the optical paths of RS and OCT sampling arms, whereby a compact long-pass dichroic mirror (LPDM) is utilized to transmit the OCT signal through a gradient index rod lens and a reflection mirror, whereas the LPDM deflects the tissue Raman signal by 90 degrees, leading to coaligned RS/OCT optical samplings on the tissue. Further study shows that the hybrid RS and OCT technique developed is capable of simultaneously acquiring both morphological and biochemical information about the oral tissue in vivo, facilitating real-time, in vivo tissue diagnoses and characterizations in the oral cavity. (C) 2016 Optical Society of America
机译：我们报告了一种独特的侧视图手持式混合拉曼光谱学（RS）和光学相干断层扫描（OCT）技术，用于实时体内组织测量。侧面手持式RS-OCT光学探头设计用于使RS和OCT采样臂的光路对齐，从而利用紧凑的长通二向色镜（LPDM）通过梯度折射率棒状透镜和反射镜传输OCT信号，而LPDM将组织拉曼信号偏转90度，从而导致在组织上进行共对准的RS / OCT光学采样。进一步的研究表明，开发的混合RS和OCT技术能够同时获取体内口腔组织的形态学和生化信息，从而促进口腔中实时，体内组织的诊断和鉴定。 （C）2016美国眼镜学会

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