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Nano-plasmonic-based structures for DNA sequencing

机译:基于纳米等离子体的DNA测序结构

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We propose novel nano-plasmonic-based structures for rapid sequencing of DNA molecules. The optical properties of DNA nucleotides have notable differences in the ultraviolet (UV) region of light. Using nanopore, bowtie, and bowtie-nanopore compound structures, probable application of the surface plasmon resonance (SPR) in DNA sequencing is investigated by employing the discrete dipole approximation method. The effects of different materials like chromium (Cr), aluminum (Al), rhodium (Rh), and graphene (Gr) are studied. We show that for Cr/ Al/ Gr/ Rh, the nucleotide presented shifts the SPR spectra for the nanopore 1/29/5/34 to 14/39/15/67 nm, bowtie 8/2/49/38 to 31/20/79/55 nm, and bowtie-nanopore compound 25/77/5/16 to 80/80/22/39 nm. The Cr-based compound structure shows excellent sensitivity and selectivity which can make it a promising methodology for DNA sequencing. (C) 2016 Optical Society of America
机译:我们提出了新颖的基于纳米等离子体的结构,用于DNA分子的快速测序。 DNA核苷酸的光学特性在光的紫外线(UV)区域具有显着差异。使用纳米孔,领结和领结-纳米孔的化合物结构,通过采用离散偶极近似方法研究了表面等离振子共振(SPR)在DNA测序中的可能应用。研究了铬(Cr),铝(Al),铑(Rh)和石墨烯(Gr)等不同材料的影响。我们表明,对于Cr / Al / Gr / Rh,所呈现的核苷酸将纳米孔的SPR光谱从1/29/5/34转移到14/39/15/67 nm,领结8/2/49/38转移到31 / 20/79/55 nm和领结-纳米孔化合物25/77/5/16至80/80/22/39 nm。 Cr基化合物的结构显示出出色的灵敏度和选择性,这使其成为一种有前途的DNA测序方法。 (C)2016美国眼镜学会

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