Depletion of Cultivatable Gut Microbiota by Broad-Spectrum Antibiotic Pretreatment Worsens Outcome After Murine Stroke

Winek Katarzyna; Engel Odilo; Koduah Priscilla; Heimesaat Markus M.; Fischer Andre; Bereswill Stefan; Dames Claudia; Kershaw Olivia; Gruber Achim D.; Curato Caterina; Oyama Naoki; Meisel Christian; Meisel Andreas; Dirnagl Ulrich

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Depletion of Cultivatable Gut Microbiota by Broad-Spectrum Antibiotic Pretreatment Worsens Outcome After Murine Stroke

机译：广谱抗生素预处理消耗可耕肠道微生物群的结果在鼠卒中后恶化。

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Background and Purpose Antibiotics disturbing microbiota are often used in treatment of poststroke infections. A bidirectional brain-gut microbiota axis was recently suggested as a modulator of nervous system diseases. We hypothesized that gut microbiota may be an important player in the course of stroke.

机译：背景与目的干扰微生物群的抗生素通常用于治疗中风后感染。最近提出了双向脑肠微生物群轴作为神经系统疾病的调节剂。我们假设肠道菌群可能是中风过程中的重要参与者。

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《Stroke: A Journal of Cerebral Circulation》 |2016年第5期|共10页
作者
Winek Katarzyna; Engel Odilo; Koduah Priscilla; Heimesaat Markus M.; Fischer Andre; Bereswill Stefan; Dames Claudia; Kershaw Olivia; Gruber Achim D.; Curato Caterina; Oyama Naoki; Meisel Christian; Meisel Andreas; Dirnagl Ulrich;
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正文语种 eng
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animal model; antibiotic; brain-gut microbiota axis; ischemic stroke; microbiota depletion;

机译：动物模型;抗生素;脑肠微生物群轴;缺血性中风;微生物群耗竭;

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1. Depletion of Cultivatable Gut Microbiota by Broad-Spectrum Antibiotic Pretreatment Worsens Outcome After Murine Stroke [J] . Winek Katarzyna, Engel Odilo, Koduah Priscilla, Stroke: A Journal of Cerebral Circulation . 2016,第5期

机译：广谱抗生素预处理消耗可耕肠道微生物群的结果在鼠卒中后恶化。
2. Culturomics and pyrosequencing evidence of the reduction in gut microbiota diversity in patients with broad-spectrum antibiotics [J] . Grégory Dubourg, Jean Christophe Lagier, Catherine Robert, International journal of antimicrobial agents . 2014,第2期

机译：文化学和焦磷酸测序证据表明，广谱抗生素患者肠道菌群多样性降低
3. Enrichment or depletion? The impact of stool pretreatment on metaproteomic characterization of the human gut microbiota [J] . Tanca Alessandro, Palomba Antonio, Pisanu Salvatore, Proteomics . 2015,第20期

机译：丰富或枯竭？粪便预处理对人类肠道微生物群蛋白质组学表征的影响
4. Early-Life Antibiotic Exposure, Gut Microbiota Development, and Predisposition to Obesity [C] . Meghan B. Azad, Shirin Moossavi, Arthur Owora, Nestlé Nutrition Workshop . 2017

机译：早期抗生素暴露，肠道微生物群发育，以及肥胖的易感性
5. Alterations in JAK/STAT signaling pathway and blood-brain barrier function: Mechanisms underlying worsened outcome following stroke in the aged rat. [D] . DiNapoli, Vincent A. 2008

机译：JAK / STAT信号传导途径和血脑屏障功能的改变：老年大鼠中风后预后恶化的潜在机制。
6. Depletion of Cultivatable Gut Microbiota by Broad-Spectrum Antibiotic Pretreatment Worsens Outcome After Murine Stroke [O] . Katarzyna Winek, Odilo Engel, Priscilla Koduah, -1

机译：广谱抗生素预处理消耗可耕肠道微生物群的结果在小鼠卒中后恶化。
7. Sleep and the gut microbiome: antibiotic-induced depletion of the gut microbiota reduces nocturnal sleep in mice [O] . Jonathan Lendrum, Bradley Seebach, Barrett Klein, 2017

机译：睡眠和肠道微生物组：抗生素诱导的肠道微生物瘤减少了小鼠的夜间睡眠

Depletion of Cultivatable Gut Microbiota by Broad-Spectrum Antibiotic Pretreatment Worsens Outcome After Murine Stroke

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