...
【24h】

Model Selection for Cox Models with Time-Varying Coefficients

机译:具有时变系数的Cox模型的模型选择

获取原文
获取原文并翻译 | 示例
           

摘要

Cox models with time-varying coefficients offer great flexibility in capturing the temporal dynamics of covariate effects on right-censored failure times. Because not all covariate coefficients are time varying, model selection for such models presents an additional challenge, which is to distinguish covariates with time-varying coefficient from those with time-independent coefficient. We propose an adaptive group lasso method that not only selects important variables but also selects between time-independent and time-varying specifications of their presence in the model. Each covariate effect is partitioned into a time-independent part and a time-varying part, the latter of which is characterized by a group of coefficients of basis splines without intercept. Model selection and estimation are carried out through a fast, iterative group shooting algorithm. Our approach is shown to have good properties in a simulation study that mimics realistic situations with up to 20 variables. A real example illustrates the utility of the method.
机译:具有随时间变化的系数的Cox模型提供了很大的灵活性,可以捕获对右删失时间的协变量影响的时间动态。由于并非所有协变量系数都随时间变化,因此针对此类模型的模型选择提出了另一项挑战,即将具有时变系数的协变量与具有时间独立系数的协变量区分开。我们提出了一种自适应组套索方法,该方法不仅可以选择重要变量,还可以在模型中将其存在的时间无关和时变的规范之间进行选择。每个协变量效应都分为一个与时间无关的部分和一个随时间变化的部分,后者的特征在于一组基本样条系数,没有截距。通过快速,迭代的群组射击算法进行模型选择和估计。我们的方法在模拟研究中显示出良好的性能,该研究模拟了最多20个变量的现实情况。一个真实的例子说明了该方法的实用性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号