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首页> 外文期刊>Critical Reviews in Food Science and Nutrition >Meta-review of protein network regulating obesity between validated obesity candidate genes in the white adipose tissue of high-fat diet-induced obese C57BL/6J mice.
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Meta-review of protein network regulating obesity between validated obesity candidate genes in the white adipose tissue of high-fat diet-induced obese C57BL/6J mice.

机译：在高脂饮食诱导的肥胖C57BL / 6J小鼠的白色脂肪组织中，通过验证的肥胖候选基因之间调节肥胖的蛋白质网络的荟萃综述。

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摘要

Worldwide obesity and related comorbidities are increasing, but identifying new therapeutic targets remains a challenge. A plethora of microarray studies in diet-induced obesity models has provided large datasets of obesity associated genes. In this review, we describe an approach to examine the underlying molecular network regulating obesity, and we discuss interactions between obesity candidate genes. We conducted network analysis on functional protein-protein interactions associated with 25 obesity candidate genes identified in a literature-driven approach based on published microarray studies of diet-induced obesity. The obesity candidate genes were closely associated with lipid metabolism and inflammation. Peroxisome proliferator activated receptor gamma (Pparg) appeared to be a core obesity gene, and obesity candidate genes were highly interconnected, suggesting a coordinately regulated molecular network in adipose tissue. In conclusion, the current network analysis approach may help elucidate the underlying molecular network regulating obesity and identify anti-obesity targets for therapeutic intervention
机译：全球肥胖症和相关合并症正在增加，但是确定新的治疗目标仍然​​是一个挑战。饮食诱发肥胖模型中的大量微阵列研究提供了肥胖相关基因的大型数据集。在这篇综述中，我们描述了一种检查潜在的调控肥胖的分子网络的方法，并讨论了肥胖候选基因之间的相互作用。我们基于已发表的饮食诱发肥胖的微阵列研究，对文献驱动方法中鉴定的与25个肥胖候选基因相关的功能性蛋白质-蛋白质相互作用进行了网络分析。肥胖候选基因与脂质代谢和炎症密切相关。过氧化物酶体增殖物激活受体γ（Pparg）似乎是核心肥胖基因，肥胖候选基因高度相关，表明在脂肪组织中分子网络的协调调控。总之，当前的网络分析方法可能有助于阐明调节肥胖的潜在分子网络，并确定用于治疗干预的抗肥胖目标

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