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首页> 外文期刊>Critical reviews in oncogenesis >Benzalkonium salts: effects on G protein-mediated processes and surface membranes.
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Benzalkonium salts: effects on G protein-mediated processes and surface membranes.

机译：苯扎氯铵盐：对G蛋白介导的过程和表面膜的影响。

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摘要

Benzalkonium salts comprise a group of positively charged surface-active alkylamine biocides with the general formula alkyldimethylbenzylammonium chloride or bromide. They interact with guanine nucleotide triphosphate-binding proteins (G proteins), thereby affecting signal transduction in a variety of cell types and processes. This article reviews the known and potential basic science research and clinical applications and manifestations of benzalkonium salts. Benzalkonium salts have antiproliferative effects on a variety of cells (including T cells) through G protein-dependent pathways, affect cytokine gene expression (downregulate tumor necrosis factor expression), and are also effective bactericidal, fungicidal, and virucidal agents with multisite (direct and immunologically mediated) inhibitory activity against many pathogens, including the human immunodeficiency virus (HIV), papillomavirus, and herpesviruses. Therefore, benzalkonium salts not only appear to be effective as disinfectants and spermicides but may also prove useful in the prevention and treatment of neoplasias and other disease, particularly those linked to viruses and originating at the skin or mucosal surface.
机译：苯甲铵盐包含一组带正电荷的表面活性烷基胺杀生物剂，其通式为烷基二甲基苄基氯化铵或溴化物。它们与鸟嘌呤核苷酸三磷酸结合蛋白（G蛋白）相互作用，从而影响多种细胞类型和过程中的信号转导。本文概述了苯扎氯铵盐的已知和潜在基础科学研究以及临床应用和表现。苯扎氯铵盐通过G蛋白依赖性途径对多种细胞（包括T细胞）具有抗增殖作用，影响细胞因子基因的表达（下调肿瘤坏死因子的表达），并且还是有效的多位杀菌剂，杀真菌剂和杀病毒剂（直接和间接）。对许多病原体，包括人类免疫缺陷病毒（HIV），乳头瘤病毒和疱疹病毒的免疫抑制作用）。因此，苯扎氯铵盐似乎不仅可用作消毒剂和杀精子剂，而且还可用于预防和治疗赘生物和其他疾病，特别是与病毒有关并起源于皮肤或粘膜表面的疾病。

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