RNA and DNA complexes with hemin [Fe(III) heme] are efficient peroxidases and peroxygenases: How do they do it and what does it mean?

SenD.; PoonL.C.H.

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RNA and DNA complexes with hemin [Fe(III) heme] are efficient peroxidases and peroxygenases: How do they do it and what does it mean?

机译：具有血红素[Fe（III）血红素]的RNA和DNA络合物是有效的过氧化物酶和过氧合酶：它们如何作用，这是什么意思？

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Guanine-rich RNAs and DNAs from chromosomal telomeres and elsewhere that fold into guanine quadruplexes (G-quadruplexes), are found to complex tightly with porphyrins such as N-methylmesoporphyrin IX (NMM) and hemin [Fe(III) heme]. By themselves, these DNAs and RNAs are found to be efficient catalysts for porphyrin metallation. When complexed with hemin, under physiological conditions, these nucleic acids display robust peroxidase (one-electron oxidation), as well as peroxygenase (two-electron oxidation, or oxygen transfer) activity. These surprising catalytic properties, that frequently match the catalytic performance of natural peroxidase and P450 monooxygenase enzymes, have been the subject of significant mechanistic analysis, as well as having found utility in a wide range of biosensing and other applications. This review summarizes recent insights into a surprising yet fundamental property of many RNAs and DNAs, a property with undoubted ramifications for cellular oxidative disease, de novo hemoenzyme design, and our understanding of the evolution of early biocatalytic systems.

机译：来自染色体端粒和其他地方的富含鸟嘌呤的RNA和DNA折叠成鸟嘌呤四联体（G-四联体）后，与卟啉如N-甲基间卟啉IX（NMM）和血红素[Fe（III）血红素]紧密结合。单独发现这些DNA和RNA是卟啉金属化的有效催化剂。当与血红素复合时，在生理条件下，这些核酸显示出强健的过氧化物酶（单电子氧化）和过氧化酶（两电子氧化或氧转移）活性。这些令人惊讶的催化性能通常与天然过氧化物酶和P450单加氧酶的催化性能相匹配，已经成为重要的机理分析的主题，并且已在广泛的生物传感和其他应用中得到应用。这篇综述总结了对许多RNA和DNA令人惊讶但基本特性的最新见解，对于细胞氧化性疾病，从头血液酶设计无可置疑的特性，以及我们对早期生物催化系统进化的理解。

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《Critical Reviews in Biochemistry and Molecular Biology》 |2011年第6期|共15页
作者
SenD.; PoonL.C.H.;
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原文格式 PDF
正文语种 eng
中图分类生物化学;
关键词
DNA; DNAzyme; Fe(III) heme; Ferrochelatase; G-quadruplex; Hemin; P450 monooxygenases; Peroxidase; Peroxygenase; Ribozyme; RNA;

机译：DNA;DNA酶;Fe（III）血红素;铁螯合酶;G-四链体;血红素;P450单加氧酶;过氧化物酶;过加氧酶;核酶;RNA;

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1. RNA and DNA complexes with hemin [Fe(III) heme] are efficient peroxidases and peroxygenases: How do they do it and what does it mean? [J] . SenD., PoonL.C.H. Critical Reviews in Biochemistry and Molecular Biology . 2011,第6期

机译：具有血红素[Fe（III）血红素]的RNA和DNA络合物是有效的过氧化物酶和过氧合酶：它们如何作用，这是什么意思？
2. Cmr1 enables efficient RNA and DNA interference of a III-B CRISPR?￠??Cas system by binding to target RNA and crRNA [J] . Wenyuan Han, Yingjun Li, Yun Xiang Liang, Nucleic acids research . 2017,第19期

机译：Cmr1通过与靶标RNA和crRNA结合而实现III-B CRISPR / Cas系统的有效RNA和DNA干扰
3. Efficient silencing of the gene coding for the epsilon subunit of DNA polymerase III in Escherichia coli is triggered by antisense RNAs featuring stability in vivo [J] . Stefan A, Tabler M, Hochkoeppler A FEMS Microbiology Letters . 2007,第2期

机译：具有体内稳定性的反义RNA触发了大肠杆菌DNA聚合酶IIIε亚基编码基因的有效沉默
4. Peroxidase Activity of G-Quadruplex Hemin-Binding DNA Aptamers Determined by Electrochemical Measurement [C] . I. Kubo, T. Eguchi, Y. Hoshino, Pacific rim meeting . 2013

机译：通过电化学测量确定的G-Quadreplex血红素结合DNA适体的过氧化物酶活性
5. Model complexes as probes of heme and nonheme enzymatic mechanisms: (1) Ferric peroxo porphyrin complexes as mimics of P450 enzymes using the ferric peroxo species as an active oxidant. (2) Strongly oxidizing iron (III) complexes as models of the active site intermediates of lipoxygenase. [D] . Wertz, Diana L. 1999

机译：将复合物建模为血红素和非血红素酶机制的探针：（1）使用过氧化铁物种作为活性氧化剂，将过氧化铁卟啉复合物模拟为P450酶。（2）强氧化铁（III）络合物作为脂氧合酶活性位点中间体的模型。
6. Cmr1 enables efficient RNA and DNA interference of a III-B CRISPR–Cas system by binding to target RNA and crRNA [O] . Yingjun Li, Yan Zhang, Jinzhong Lin, 2017

机译：Cmr1通过与靶标RNA和crRNA结合实现III-B CRISPR-Cas系统的有效RNA和DNA干扰。
7. Cmr1 enables efficient RNA and DNA interference of a III-B CRISPR–Cas system by binding to target RNA and crRNA [O] . Yingjun Li, Yan Zhang, Jinzhong Lin, 2017

机译：CMR1通过与靶RNA和CRRNA结合，通过结合靶标和CRRNA来实现III-B CISSPR-CAS系统的有效RNA和DNA干扰
8. Quantum Mixed-Spin Heme State of Barley Peroxidase: A Paradigm for Class III Peroxidases;Biophysical Journal [R] . Howes, B. D. , Ma, J. , Marzocchi, M. P. , 1999

机译：大麦过氧化物酶的量子混合自旋状态：III类过氧化物酶的范例;生物物理杂志

RNA and DNA complexes with hemin [Fe(III) heme] are efficient peroxidases and peroxygenases: How do they do it and what does it mean?

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