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Pterostilbene: Biomedical applications

机译:蝶芪:生物医学应用

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摘要

Resveratrol and its naturally dimethylated analog, pterostilbene, show similar biological activities. However, the higher in vivo bioavailability of pterostilbene represents a fundamental advantage. The main focus of this review is on biomedical applications of pterostilbene. The metabolism and pharmacokinetics of this stilbene in inflammatory dermatoses and photoprotection, cancer prevention and therapy, insulin sensitivity, blood glycemia and lipid levels, cardiovascular diseases, aging, and memory and cognition are addressed. Safety and toxicity, as well as recommendations for future research and biomedical uses, are discussed. This review includes comparisons between pterostilbene and other polyphenols, with particular emphasis on resveratrol. Potential benefits of using combinations of different polyphenols are considered. Based on present evidences we conclude that pterostilbene is an active phytonutrient and also a potential drug with multiple biomedical applications.
机译:白藜芦醇及其天然的二甲基化类似物翼戊二烯具有相似的生物活性。但是,紫檀二烯在体内的生物利用度较高,这是一个基本优势。这项审查的主要重点是在翼龙的生物医学应用。该二苯乙烯在炎症性皮肤病和光保护,癌症预防和治疗,胰岛素敏感性,血糖和血脂水平,心血管疾病,衰老以及记忆和认知方面的代谢和药代动力学得到了解决。讨论了安全性和毒性,以及对未来研究和生物医学用途的建议。这篇综述包括了对蝶形苯与其他多酚的比较,特别是白藜芦醇。考虑使用不同多酚组合的潜在益处。根据目前的证据,我们得出结论,蕨类植物是一种有效的植物营养素,也是具有多种生物医学应用潜力的药物。

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