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首页> 外文期刊>Croatian medical journal >Application of the procedural consolidation concept to surgical treatment of children with epidermolysis bullosa: a retrospective analysis.
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Application of the procedural consolidation concept to surgical treatment of children with epidermolysis bullosa: a retrospective analysis.

机译：程序合并概念在大疱性表皮松解症儿童手术治疗中的应用：回顾性分析。

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AIM: To assess the efficacy of the procedural consolidation concept (PCC) at reducing the number of sessions of general anesthesia necessary for treating children with epidermolysis bullosa (EB). METHODS: We examined the records of children treated at Children's Hospital of Zagreb between April 1999 and December 2007. Children treated before the introduction of PCC in January 2005 (n=39) and after (n=48) were analyzed in order to determine the effect of PCC on the occurrence of complications, days of hospitalization, and number of hospitalizations. RESULTS: During the study period, 53 patients underwent 220 sessions of general anesthesia for a total of 743 surgical interventions per session. Before the introduction of PCC (n=39 patients, 83 sessions), the median number of interventions per session was 2 (range 1-5), and after the introduction of PCC (n=48 patients, 137 sessions) it was 4 (range 3-7, P<0.001). After the introduction of PCC, the median number of complications per anesthesia session increased from 2 (range 0-10) to 3 (range 0-10) (P=0.027), but the median number of complications per surgical procedure decreased from 1 (range 0-10) to 0.6 (range 0-2.5) (P<0.001). PCC lengthened each anesthesia session from a median of 65 minutes (range 35-655) to 95 minutes (range 50-405), (P<0.001). Total length of hospitalization was similar before (median 1, range 1-4) and after (median 1, range 1-3) introduction of PCC (P=0.169). The number of hospitalization days per procedure was 3 times lower after the introduction of PCC (median 0.3, range 0.2-3) than before (median 1, range 0.75-1.7) (P<0.001). CONCLUSION: PCC should be considered an option in the surgical treatment of children with EB.
机译：目的：评估程序合并概念（PCC）在减少治疗大疱性表皮松解（EB）患儿所需的全麻次数方面的功效。方法：我们检查了1999年4月至2007年12月在萨格勒布儿童医院接受治疗的儿童的记录。分析了2005年1月引入PCC之前（n = 39）和之后（n = 48）治疗的儿童，以确定患儿的病情。 PCC对并发症的发生，住院天数和住院次数的影响。结果：在研究期间，有53例患者接受了220次全身麻醉，每期总共743例外科手术。引入PCC之前（n = 39例患者，共83次），每期干预的中位数为2（范围1-5），而引入PCC（n = 48患者，137例次）后为4（范围3-7，P <0.001）。引入PCC后，每次麻醉并发症的中位数从2（范围0-10）增加到3（范围0-10）（P = 0.027），但是每次手术并发症的中位数从1（范围0-10）至0.6（范围0-2.5）（P <0.001）。 PCC将每次麻醉时间从中位数65分钟（范围35-655）延长至95分钟（范围50-405），（P <0.001）。引入PCC之前（中位数1，范围1-4）和之后（中位数1，范围1-3）的总住院时间相似（P = 0.169）。引入PCC后，每个手术的住院天数（中位数0.3，范围0.2-3）比之前（中位数1，范围0.75-1.7）低3倍（P <0.001）。结论：PCC应被认为是EB儿童手术治疗的一种选择。

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