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首页> 外文期刊>Cornea >Pilot study on the influence of corneal biomechanical properties over the short term in response to corneal refractive therapy for myopia.
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Pilot study on the influence of corneal biomechanical properties over the short term in response to corneal refractive therapy for myopia.

机译：角膜屈光疗法对近视的影响短期内对角膜生物力学特性影响的试验研究。

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PURPOSE: To study the short-term corneal response to corneal refractive therapy for myopia and correlate it with corneal biomechanical properties as measured with the ocular response analyzer. METHODS: Eight eyes from 8 young subjects were fitted with a reverse geometry contact lens, attempting a myopic correction of -4.00 D. Corneal resistance factor and corneal hysteresis (CH) were measured before contact lens fitting with the ocular response analyzer. These parameters were correlated with the degree of change in apical curvature, simulated keratometry, and central corneal thickness after 3 hours of contact lens wear (effect) and 3 hours after lens removal (recovery). RESULTS: There was a trend toward a faster effect and faster recovery of the orthokeratologic effect for corneas with less resistance in terms of biomechanical properties. Corneal resistance factor did not correlate significantly, however, with any of the topographic and pachymetric parameters. Conversely, CH was significantly correlated with changes in steep keratometry (0.758; P = 0.029) and central corneal thickness (0.755; P = 0.030) during lens wear and with changes in steep keratometry (-0.835; P = 0.010) during recovery. Overall, higher values of CH meant slower effect and recovery of the orthokeratologic effect. CONCLUSIONS: Short-term response of human cornea to corneal refractive therapy is correlated with the biomechanical properties of the cornea. Of the different theories supporting such involvement of corneal response to reverse geometry contact lenses, the most likely one seems to be the one assuming a faster response and faster recovery for corneas with lower resistance. Larger sample studies would be needed to clarify the involvement of corneal biomechanical properties on corneal response to orthokeratology.
机译：目的：研究近视对角膜屈光疗法的短期角膜反​​应，并将其与通过眼反应分析仪测得的角膜生物力学特性相关联。方法：对来自8位年轻受试者的八只眼睛配戴反向几何形状的隐形眼镜，尝试进行近视矫正-4.00D。在将角膜接触镜安装到眼睛响应分析仪之前，先测量角膜抵抗因子和角膜滞后（CH）。这些参数与角膜接触镜磨损3小时后（效果）和摘除晶体3小时后（恢复）的顶曲率，模拟角膜曲率和角膜中央厚度的变化程度相关。结果：存在一种趋势，即对于角膜的生物力学特性而言，抵抗力较小的角膜塑形镜效果更快且恢复更快。但是，角膜阻力因子与任何地形和测厚参数均无显着相关性。相反，在晶状体配戴期间，CH与陡度角膜曲率的变化（0.758; P = 0.029）和角膜中央厚度（0.755; P = 0.030）显着相关，并且在恢复过程中与陡度角膜曲率的变化（-0.835; P = 0.010）密切相关。总体而言，较高的CH值意味着效果较慢且恢复了角膜塑形学效果。结论：人角膜对角膜屈光疗法的短期反应与角膜的生物力学特性相关。在支持角膜对反向几何形状隐形眼镜的这种反应的不同理论中，最有可能的理论似乎是对具有较低抵抗力的角膜假设更快的响应和更快的恢复的理论。需要更大的样本研究来阐明角膜对角膜塑形反应的生物力学特性。

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