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首页> 外文期刊>Cornea >Confocal microscopy in chronic and delayed mustard gas keratopathy.
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Confocal microscopy in chronic and delayed mustard gas keratopathy.

机译：共聚焦显微镜在慢性芥子气角化病和迟发性芥子气角化病中的应用。

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PURPOSE: To evaluate in vivo confocal microscopic features of the cornea in chronic and delayed mustard gas keratopathy (MGK). DESIGN: Comparative cross-sectional study. PARTICIPANTS AND CONTROLS: Twenty-two eyes of 22 consecutive patients with MGK and 28 eyes of 28 normal unoperated subjects were enrolled. METHODS: All subjects underwent corneal confocal scanning, and the findings were compared between the 2 groups. MAIN OUTCOME MEASURES: Qualitative (layer thickness measurement and cell count) and quantitative (nerve and deposit evaluation) findings of corneal confocal scanning. RESULTS: All subjects with MGK and normal subjects were males, with no significant difference in mean age between the 2 groups. Mean central corneal thickness, mean epithelial thickness, mean cell density of basal epithelia, keratocyte density at 3 stromal layers, and endothelial cell density in the MGK group were significantly lower than those in the control group. Loss of keratocytes was predominantly observed in the anterior to middle stroma. In vivo confocal microscopy revealed lack of a subbasal nerve plexus, presence of intrastromal hyperreflective microdots, prominent thickened midstromal nerves, enlarged bizarre-looking keratocytes, amyloid degeneration, lipid keratopathy, posterior stromal folds, and endothelial cell pleomorphism and polymegathism. CONCLUSIONS: Corneal thinning, significant loss of keratocytes together with pleomorphic residual keratocytes, thickened midstromal nerve, stromal microdots, amyloid degeneration, and lipid keratopathy were remarkable findings observed in our cases. Although all the corneal layers were affected significantly by mustard gas, the anterior to middle parts of the cornea were more involved than the posterior parts.
机译：目的：评估慢性和延迟性芥子气性角化病（MGK）中角膜的体内共聚焦显微镜特征。设计：比较横断面研究。参与者和对照：纳入22例连续的MGK患者的22眼和28例正常非手术患者的28眼。方法：所有受试者均接受角膜共聚焦扫描，并比较两组的发现。主要观察指标：角膜共聚焦扫描的定性（层厚度测量和细胞计数）和定量（神经和沉积物评估）结果。结果：所有患有MGK的受试者和正常受试者均为男性，两组之间的平均年龄无显着差异。 MGK组的平均中央角膜厚度，平均上皮厚度，基底上皮的平均细胞密度，3基质层的角膜细胞密度和内皮细胞密度均显着低于对照组。角质细胞的丢失主要在中层间质的前部观察到。体内共聚焦显微镜检查发现缺乏基底下神经丛，存在基质内高反射性微点，明显增厚的中层基质神经，奇异的角化细胞，淀粉样变性，脂质角化病，基质后部褶皱以及内皮细胞多态性和多形性。结论：在我们的病例中发现了明显的结果，角膜变薄，角膜细胞大量丢失以及多形性残留角膜细胞，中层神经增厚，基质微粒，淀粉样变性和脂质性角膜病变。尽管所有角膜层均受到芥子气的显着影响，但角膜的前部至中部比后部受累更多。

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