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首页> 外文期刊>Biochimica et biophysica acta. Molecular basis of disease: BBA >Antioxidant properties of colchicine in acute carbon tetrachloride induced rat liver injury and its role in the resolution of established cirrhosis
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Antioxidant properties of colchicine in acute carbon tetrachloride induced rat liver injury and its role in the resolution of established cirrhosis

机译：秋水仙碱在急性四氯化碳诱导的大鼠肝损伤中的抗氧化特性及其在解决肝硬化中的作用

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Antioxidant and antifibrotic properties of colchicine were investigated in the carbon tetrachloride (CCl_4) rat model. (1) The protective effect of colchicine pretreatment on CCl_4 induced oxidant stress was examined in rats subsequently receiving a single lethal dose of CCl_4. Urinary 8-isoprostane, kidney and liver malondialdehyde and kidney glutathione levels increased following CCl_4 treatment, but only the rise in kidney malondialdehyde was significantly inhibited by colchicine pretreatment. Serum total antioxidant levels were significantly higher in the colchicine pretreatment group. (2) The long term effects of colchicine treatment on CCl_4 induced liver damage were investigated using liver histology and biochemical markers (hydroxyproline and type III procollagen peptide). Co-administration of colchicine with sub-lethal doses of CCl_4 over 10 weeks did not prevent progression to cirrhosis. However, rats made cirrhotic with repeated CCl_4 challenge and subsequently treated with colchicine for 12 months, all showed histological regression of cirrhosis. (3) The antioxidant effect of colchicine in vitro was evident only at very high concentrations compared to other plasma antioxidants. In summary, colchicine has only weak antioxidant properties, but does afford some protection against oxidative stress; more importantly, long term treatment with this drug may be of value in producing regression of established cirrhosis.
机译：在四氯化碳（CCl_4）大鼠模型中研究了秋水仙碱的抗氧化和抗纤维化特性。 （1）在随后接受单次致死剂量的CCl_4的大鼠中检查了秋水仙碱预处理对CCl_4诱导的氧化应激的保护作用。 CCl_4处理后尿中的8-异前列腺素，肾脏和肝脏的丙二醛和肾脏的谷胱甘肽水平升高，但是秋水仙碱预处理仅显着抑制了肾脏中的丙二醛的升高。秋水仙碱预处理组的血清总抗氧化剂水平明显更高。 （2）使用肝脏组织学和生化指标（羟脯氨酸和III型胶原蛋白原），研究了秋水仙碱治疗对CCl_4诱导的肝损伤的长期影响。秋水仙碱与亚致死剂量的CCl_4并用10周以上不能预防肝硬化的发展。然而，大鼠经反复CCl_4攻击后变为肝硬化，随后用秋水仙碱治疗12个月，均显示出肝硬化的组织学消退。 （3）与其他血浆抗氧化剂相比，秋水仙碱的体外抗氧化作用仅在非常高的浓度下才可见。总之，秋水仙碱仅具有弱的抗氧化性能，但确实提供了一些抗氧化应激的保护。更重要的是，用这种药物进行长期治疗可能对使已确立的肝硬化消退具有重要意义。

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