...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cornea >Importance of nutrition to corneal grafts when used as a carrier of the Boston Keratoprosthesis.
【24h】

Importance of nutrition to corneal grafts when used as a carrier of the Boston Keratoprosthesis.

机译：当用作波士顿角膜移植术的载体时，营养对角膜移植物的重要性。

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

PURPOSE: Necrosis, melt, and perforation have historically been frequent around a Keratoprosthesis (KPro), even resulting in extrusion or endophthalmitis. Autoimmune diseases such as Stevens-Johnson Syndrome (SJS) and Ocular Cicatricial Pemphigoid (OCP) have been notorious in this respect. The purpose of this study was to compare the frequency of tissue melt after implantation of two designs of the Boston KPro, one allowing much better access of nutrition from the aqueous humor to the carrier graft. METHODS: We retrospectively reviewed charts of 157 eyes implanted since 1990 with a poly (methylmethacrylate) Boston KPro, including 79 eyes implanted with the model having 8 small (1.3-mm diameter) holes in the back plate, and 78 eyes implanted with the older solid back plate. We compared the frequency of tissue melts between the two KPro designs, for all implants as well as for subgroups based on preoperative diagnosis. RESULTS: In total, 48/157 eyes (31%) developed some degree of tissue melt around the stem, including 8/79 eyes (10%) in the back plate with holes group and 40/78 eyes (51%) in the solid back plate group (P < 0.0001). Among the melts in the back plate with holes group, 4/8 (50%) suffered from an underlying autoimmune disease such as SJS or OCP. CONCLUSIONS: The Boston KPro design with a back plate containing holes protects the overlying corneal tissue from necrosis and melts. This improved situation is likely due to increased aqueous access and better nutrition to the corneal graft cells. In addition, this study confirms earlier work regarding the particular corneal fragility of patients with autoimmune diseases.
机译：目的：历史上，角化假肢（KPro）周围经常发生坏死，融化和穿孔，甚至导致挤压或眼内炎。在这方面，诸如史蒂文斯-约翰逊综合症（SJS）和眼部瘢痕性天疱疮（OCP）等自身免疫性疾病众所周知。这项研究的目的是比较两种设计的Boston KPro植入后组织融化的频率，其中一种允许从房水到载体移植物更好地获取营养。方法：我们回顾性分析了自1990年以来植入聚甲基丙烯酸甲酯波士顿KPro的157眼的图表，包括79眼植入模型的后板上有8个小孔（直径1.3毫米）的孔，以及78眼植入较老的模型的图表。坚固的背板。我们根据术前诊断比较了两种KPro设计，所有植入物以及亚组的组织融化频率。结果：总共有48/157眼（31％）在茎周围出现了一定程度的组织融化，包括带孔组的背板中有8/79眼（10％），而在孔中有40/78眼（51％）。实心背板组（P <0.0001）。在带孔背板的熔体中，有4/8（50％）患有潜在的自身免疫性疾病，例如SJS或OCP。结论：带有孔的后板的Boston KPro设计可保护上方的角膜组织免于坏死和融化。这种情况的改善可能是由于增加了水通道和对角膜移植细胞的营养。此外，这项研究证实了有关自身免疫性疾病患者特定角膜脆性的早期工作。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号