...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Coronary artery disease >Distribution of left ventricular ejection fraction in angina patients with severe coronary artery disease not amenable to revascularization.
【24h】

Distribution of left ventricular ejection fraction in angina patients with severe coronary artery disease not amenable to revascularization.

机译：严重冠心病不宜血管重建的心绞痛患者左心室射血分数的分布。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: As the number of angina patients with severe coronary artery disease not amenable to revascularization increases, new therapies will be developed. How patients with depressed compared to normal left ventricular ejection fraction (LVEF) will respond to new therapies may differ. HYPOTHESIS: We conducted a retrospective chart review to determine the distribution of LVEF in angina patients with severe coronary artery disease (three-vessel disease with >50% stenosis major epicardial vessels or >50% stenosis left main) not amenable to revascularization. METHODS: Patients underwent cardiac catheterization between 2004 and 2009. LVEF, measured by echocardiography, nuclear-gated imaging or radioventriculography within 6 months of catheterization, was recorded. Demographics, symptoms, risk factors, past myocardial infarction, catheterization results, medications, and the Duke Coronary Artery Jeopardy Score were recorded. RESULTS: Eight thousand six hundred and ninety-nine patient charts were reviewed; 124 met criteria. There was a continuous, and not bimodal, distribution of LVEF. Fifty-eight patients (47%) in the normal LVEF group were compared to 66 patients (53%) in the abnormal LVEF group (<50%). The two groups were statistically different only with respect to shortness of breath as a presenting symptom and diagnosis of congestive heart failure during index hospitalization. Follow-up mortality was high and did not differ between LVEF groups (35% vs. 34%). CONCLUSION: There is a wide distribution of LVEF among angina patients not amenable to revascularization. A novel finding of this study showed that mortality was high regardless of LVEF. As new therapies for angina are developed, attention will need to be paid to how such therapies affect these two patient groups.
机译：背景：随着严重的冠心病不适合血运重建的心绞痛患者人数的增加，将开发新的疗法。与正常左心室射血分数（LVEF）相比抑郁的患者对新疗法的反应可能有所不同。假设：我们进行了回顾性图表审查，以确定LVEF在严重冠状动脉疾病（三血管疾病，主动脉瓣狭窄> 50％狭窄或主动脉狭窄> 50％狭窄）的不宜血管重建的患者中的分布。方法：2004年至2009年间对患者进行了心脏导管插入术。记录了在插入导管后6个月内通过超声心动图，核门控成像或放射室描记术测量的LVEF。记录人口统计学，症状，危险因素，既往心肌梗塞，导管插入结​​果，药物和杜克冠状动脉危险评分。结果：审查了八千六百九十九个患者图表。 124个符合标准。 LVEF有连续分布，而不是双峰分布。 LVEF正常组的58例患者（47％）与LVEF异常组的<66％（53％）（<50％）相比较。两组之间的差异仅在于呼吸急促症状的出现和指数住院期间充血性心力衰竭的诊断。 LVEF组之间的随访死亡率很高，无差异（35％vs. 34％）。结论：不适合血管重建的心绞痛患者中LVEF分布广泛。这项研究的新发现表明，不管LVEF如何，死亡率都很高。随着用于心绞痛的新疗法的发展，将需要注意这种疗法如何影响这两个患者组。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号