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On the generation and ownership of alpha in medical studies.

机译：关于医学研究中alpha的生成和所有权。

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Much is known about how to split alpha between or among several comparisons, or how to preserve the nominal alpha level with an exact analysis, but the issue of how alpha is generated, or where it comes from, has not received a commensurate degree of attention. It would seem that there is little point in working out methods to allocate or conserve alpha if it is unlimited in supply. Moreover, there seems to be a logical inconsistency in requiring that a given amount of alpha, generally 0.05, be split among the primary comparisons performed by a given set of researchers, yet allowing other researchers to analyze the same data with a new 0.05 to work with. We will address these inconsistencies, and ask more generally where alpha comes from, how it can be generated, and under what conditions it should be one-tailed or two-tailed.
机译：关于如何在多个比较之间或之间进行比较，或者如何通过精确的分析来保持标称阿尔法水平的了解很多，但是关于如何产生阿尔法或它来自何方的问题尚未引起应有的重视。 。如果供应量不受限制，那么似乎很难找到分配或保存alpha的方法。此外，在要求给定一组研究人员进行的主要比较之间分配给定数量的alpha（通常为0.05）似乎存在逻辑上的矛盾，但允许其他研究人员使用新的0.05进行相同的数据分析用。我们将解决这些不一致之处，并更普遍地询问alpha的来源，如何生成以及在什么条件下应将其单尾或双尾。

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