Designing a highly active soluble PQQ-glucose dehydrogenase for efficient glucose biosensors and biofuel cells.

Durand F; Stines Chaumeil C; Flexer V; Andre I; Mano N

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Designing a highly active soluble PQQ-glucose dehydrogenase for efficient glucose biosensors and biofuel cells.

机译：设计用于高效葡萄糖生物传感器和生物燃料电池的高活性可溶性PQQ-葡萄糖脱氢酶。

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We report for the first time a soluble PQQ-glucose dehydrogenase that is twice more active than the wild type for glucose oxidation and was obtained by combining site directed mutagenesis, modelling and steady-state kinetics. The observed enhancement is attributed to a better interaction between the cofactor and the enzyme leading to a better electron transfer. Electrochemical experiments also demonstrate the superiority of the new mutant for glucose oxidation and make it a promising enzyme for the development of high-performance glucose biosensors and biofuel cells.

机译：我们首次报告了可溶性PQQ-葡萄糖脱氢酶，其活性比野生型葡萄糖氧化活性高两倍，是通过结合定点诱变，建模和稳态动力学获得的。观察到的增强归因于辅因子和酶之间更好的相互作用，导致更好的电子转移。电化学实验还证明了该新突变体在葡萄糖氧化方面的优越性，使其成为开发高性能葡萄糖生物传感器和生物燃料电池的有前途的酶。

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《Biochemical and Biophysical Research Communications》 |2010年第4期|共5页
作者
Durand F; Stines Chaumeil C; Flexer V; Andre I; Mano N;
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正文语种 eng
中图分类生物化学;
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1. Designing a highly active soluble PQQ-glucose dehydrogenase for efficient glucose biosensors and biofuel cells. [J] . Durand F, Stines Chaumeil C, Flexer V, Biochemical and Biophysical Research Communications . 2010,第4期

机译：设计用于高效葡萄糖生物传感器和生物燃料电池的高活性可溶性PQQ-葡萄糖脱氢酶。
2. Electrochemical glucose biosensor by electrostatic binding of PQQ-glucose dehydrogenase onto self-assembled monolayers on gold [J] . Young-Pil Kim, Sang Jin Park, Dohoon Lee, Journal of Applied Electrochemistry . 2012,第6期

机译：通过将PQQ-葡萄糖脱氢酶静电结合到金上自组装单分子膜上的电化学葡萄糖生物传感器
3. Engineered PQQ-Glucose Dehydrogenase as a Universal Biosensor Platform [J] . Zhong Guo, Lindy Murphy, Viktor Stein, Journal of the American Chemical Society . 2016,第32期

机译：工程化的PQQ-葡萄糖脱氢酶作为通用生物传感器平台
4. PQQ-Glucose Dehydrogenase-Calmodulin Chimera Enzyme: Different Triggered Activation for Multipurpose Biosensors [C] . Paolo Bollella, Artem Melman, Zhong Guo, Meeting of the Electrochemical Society;International Meeting on Chemical Sensors . 2020

机译：PQQ-葡萄糖脱氢酶 - 钙调蛋白嵌合酶：不同触发的多功能生物传感器的激活
5. The development of ferrocene-modified linear poly(ethylenimine) redox polymers and their application in amperometric glucose biosensors and compartment-less biofuel cells [D] . Meredith, Matthew 2010

机译：二茂铁改性的线性聚乙烯亚胺氧化还原聚合物的开发及其在安培型葡萄糖生物传感器和无隔室生物燃料电池中的应用
6. Characterization of different FAD-dependent glucose dehydrogenases for possible use in glucose-based biosensors and biofuel cells [O] . Muhammad Nadeem Zafar, Najat Beden, Dónal Leech, -1

机译：表征可能用于基于葡萄糖的生物传感器和生物燃料电池中的不同FAD依赖性葡萄糖脱氢酶
7. Characterization of different FAD-dependent glucose dehydrogenases for possible use in glucose-based biosensors and biofuel cells. [O] . Zafar, MNadeem, Beden, Najat, Leech, Dónal, 2012

机译：表征不同的FaD依赖性葡萄糖脱氢酶，可用于基于葡萄糖的生物传感器和生物燃料电池。

Designing a highly active soluble PQQ-glucose dehydrogenase for efficient glucose biosensors and biofuel cells.

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