New and efficient synthesis of 5'-amino-5'-(S)-methyl-2',5'-dideoxynucleosides

Pierre M. J. Jung; Renaud Beaudegnies; Alain De Mesmaeker; Sebastian Wendeborn

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New and efficient synthesis of 5'-amino-5'-(S)-methyl-2',5'-dideoxynucleosides

机译：5'-氨基-5'-（S）-甲基-2'，5'-二脱氧核苷的新型高效合成

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摘要

A short, efficient synthesis of 5'-amino-5'-(S)-methyl-2',5'-dideoxynucleosides 1 has been developed through the diastereoselective addition of methylmagnesium bromide or methyllithium to an intermediate tert-butylsulfinimide.

机译：通过将甲基溴化镁或甲基锂非对映选择性地添加到中间的叔丁基亚磺酰亚胺中，已经开发了一种短而有效的5'-氨基-5'-（S）-甲基-2'，5'-二脱氧核苷合成方法。

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《Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry》 |2003年第2期|共5页
作者
Pierre M. J. Jung; Renaud Beaudegnies; Alain De Mesmaeker; Sebastian Wendeborn;
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正文语种 eng
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5'-amino-5'-(S)-methyl-2'; 5'-dideoxynucleosides; tert-butylsulfinamide; nucleophilic addition;

机译：5'-氨基-5'-（S）-甲基-2';5'-二脱氧核苷;叔丁基亚磺酰胺;亲核加成;

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1. New and efficient synthesis of 5'-amino-5'-(S)-methyl-2',5'-dideoxynucleosides [J] . Pierre M. J. Jung, Renaud Beaudegnies, Alain De Mesmaeker, Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2003,第2期

机译：5'-氨基-5'-（S）-甲基-2'，5'-二脱氧核苷的新型高效合成
2. Synthesis and chromatographic study of methyl-2,3-O-isopropylidene-5-dimethyl-arsinoyl-beta-D-ribofuranoside and methyl-2,3-O-isopropylidene-5-deoxy-5-dimethyl-thioarsinoyl-beta-D-ribofuranoside [J] . Gyepes A, Schaffer R, Bajor G, Polyhedron: The International Journal for Inorganic and Organometallic Chemistry . 2008,第12期

机译：甲基-2,3-O-异亚丙基-5-二甲基-砷酰基-β-D-呋喃呋喃糖苷和甲基-2,3-O-异亚丙基-5-脱氧-5-二甲基-硫代砷酰基-β-D的合成及色谱研究-核呋喃糖苷
3. Stereoselecitve synthesis of 2',3'-dideoxynucleosides by addition of selenium electrophiles to glycals. A formal synthesis of D4T from 2-deoxyribose [J] . Yolanda Diaz, Anas El-Laghdach The Journal of Organic Chemistry . 1997,第5期

机译：通过将硒亲电试剂加到糖中来合成2'，3'-二脱氧核苷的立体异构体。由2-脱氧核糖正式合成D4T
4. MICROWAVE ASSISTED SYNTHESIS OF SOME NEW 3-(4-AMINO-5-THIOXO-1,2,4-TRIAZOLE-3-YL)METHYL-2(3H)-BENZOXAZOLONE DERIVATIVES AS ANTIMICROBIAL AGENTS [C] . Solen URLU, Tijen ONKOL, M. Fethi SAHIN European Symposium on Organic Chemistry . 2009

机译：微波辅助合成一些新的3 - （4-氨基-5-硫代-1,2,4-三唑-3-基）甲基 -2（3H） - 低恶唑酮衍生物作为抗微生物剂
5. Part I: Synthesis of 2'-Fluoro-2',3'-Dideoxynucleosides as Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase. Part II: Synthesis of Cyclobutyl Phosphonate and Phosphoramidate Prodrugs for Inhibition of HIV Reverse Transcriptase [D] . Neuman, Annette Welty 2013

机译：第一部分：2'-Fluoro-2'，3'-Dideoxynucleosides的合成作为丙型肝炎病毒RNA依赖性RNA聚合酶的抑制剂。第二部分：抑制HIV逆转录酶的膦酸环丁酯和氨基磷酸酯前药的合成
6. Microbial Reduction of 13-Dioxo-2-Methyl-2-(3′-Oxo-6′-Carbomethoxyhexyl)-Cyclopentane to Form 1β-Hydroxy-3-Oxo-2β-Methyl-2α-(3′-Oxo-6′-Carbomethoxy-hexyl)-Cyclopentane an Intermediate for Steroid Total Synthesis [O] . Raymond P. Lanzilotta, Dorothy G. Bradley, Colin C. Beard 1975

机译：13-二氧-2-甲基-2-（3-Oxo-6-羧甲氧基己基）-环戊烷的微生物还原反应生成1β-羟基-3-Oxo-2β-甲基-2α-（3-Oxo- 6-羧甲氧基-己基）-环戊烷类固醇全合成中间体
7. Aminoglycoside antibiotics: Synthesis of 5"-amino-5"-deoxyneomycin and 5"-amino-5"-deoxyparomomycin. [O] . STEPHEN HANESSIAN, ROBERT MASSÉ, MARIE-LOUISE CAPMEAU 1977

机译：氨基糖苷抗生素：合成5“氨基-5” - 丁氧霉素和5“ - 氨基-5” - 丁氧基霉素。

New and efficient synthesis of 5'-amino-5'-(S)-methyl-2',5'-dideoxynucleosides

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