Stereoselective construction of the ABC-ring system of fusidane triterpenes via intermolecular/transannular Michael reaction cascade

Tomohiro Fujii; Masahisa Nakada

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Stereoselective construction of the ABC-ring system of fusidane triterpenes via intermolecular/transannular Michael reaction cascade

机译：分子间/跨环迈克尔反应级联的富丁烷三萜ABC环系统的立体选择性构建

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A stereoselective construction of the ABC-ring system of fusidane triterpenes via intermolecular/transannular Michael reaction cascade is described. The substrate, a ten-membered carbocyclic ketone, has been successfully prepared by the Cr-mediated intramolecular alkenylation of the corresponding acyclic compound. The array of functionalities in the product stereoselectively obtained by the cascade reaction is useful for further structural modifications directed toward the total synthesis of fusidane and other triterpenes, and designed molecules intended for studying structure-activity relationships.

机译：描述了通过分子间/跨环迈克尔反应级联的富丁烷三萜的ABC-环系统的立体选择性结构。通过相应的无环化合物的Cr介导的分子内烯基化已成功制备了十元碳环酮底物。通过级联反应立体选择性地获得的产物中的功能性阵列可用于进一步的修饰，这些修饰涉及夫西丹和其他三萜的全合成，以及设计用于研究结构与活性关系的分子。

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《Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry》 |2014年第9期|共5页
作者
Tomohiro Fujii; Masahisa Nakada;
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正文语种 eng
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关键词
Fusidane; Stereoselective; Intermolecular; Transannular; Michael reaction;

机译：Fusidane;立体选择性;分子间;跨环;Michael反应;

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1. Stereoselective construction of the ABC-ring system of fusidane triterpenes via intermolecular/transannular Michael reaction cascade [J] . Tomohiro Fujii, Masahisa Nakada Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2014,第9期

机译：分子间/跨环迈克尔反应级联的富丁烷三萜ABC环系统的立体选择性构建
2. Highly stereoselective construction of tetrahydroquinolines via cascade aza-Michael-Michael reaction: Formal [4+2] cycloaddition of beta,gamma-unsaturated alpha-ketoesters with 2-aminochalcones [J] . Duan Cong, Yao Yongqi, Ye Ling, Tetrahedron . 2018,第50期

机译：通过Cascade Aza-Michael-Michael反应的高度立体化结构，通过Cascade Aza-Michael-Michael反应：β，γ-不饱和α-酮酯的正式[4 + 2]环加成剂，具有2氨基氨基
3. organocatalyzed stereoselective construction of N-formylpiperidines via a Michael-aza-Henry-hemiaminalization reaction cascade [J] . Ruchi Chawla, Ankita Rai, Atul K. Singh Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2012,第39期

机译：N-甲酰基哌啶通过Michael-Aza-Henry-半胱氨酸化反应级联的有机催化立体选择性构建
4. Development and Application of Organocatalyzed Stereoselective Umpolung Double Michael Reaction [C] . Kenta Kishi, Shinobu Takizawa, Hiroaki Sasai 日本化学会春季年会講演予稿集 . 2018

机译：有机催化立体选择umpolung双迈克尔反应的开发与应用
5. I. Stereoselective Construction of Polycyclic Architectures: Enantioselective Catalytic Transannular Ketone-Ene Reactions and an Enantioselective Total Synthesis of (+)-Reserpine II. Synthesis of Chiral Bisthioureas for Anion-Abstraction Catalysis. [D] . Rajapaksa, Naomi Samadara. 2013

机译：I.多环结构的立体选择性构建：对映选择性催化环戊酮-烯反应和（+）-利血平的对映选择性总合成II。用于阴离子提取催化的手性双硫脲的合成。
6. Cascade Intramolecular N-Arylation/Intermolecular Carboamination Reactions for the Construction of Tricyclic Heterocycles [O] . Georgia S. Lemen, John P. Wolfe -1

机译：级联的分子内N-芳基化/分子间Carboamination反应为三环杂环的构建
7. Benzothiazines in Organic Synthesis. Stereoselectivity in the Intermolecular Michael Addition Reactions of Benzothiazines [O] . -1

机译：苯并噻嗪在有机合成中。苯噻嗪的分子间迈克尔加法反应中的立体选择性

Stereoselective construction of the ABC-ring system of fusidane triterpenes via intermolecular/transannular Michael reaction cascade

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