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首页> 外文期刊>The Analyst: The Analytical Journal of the Royal Society of Chemistry: A Monthly International Publication Dealing with All Branches of Analytical Chemistry >Metabolic fingerprinting in disease diagnosis: biomedical applications of infrared and Raman spectroscopy
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Metabolic fingerprinting in disease diagnosis: biomedical applications of infrared and Raman spectroscopy

机译：代谢指纹图谱在疾病诊断中的应用：红外和拉曼光谱的生物医学应用

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摘要

The ability to diagnose the early onset of disease, rapidly, non-invasively and unequivocally has multiple benefits. These include the early intervention of therapeutic strategies leading to a reduction in morbidity and mortality, and the releasing of economic resources within overburdened health care systems. Some of the routine clinical tests currently in use are known to be unsuitable or unreliable. In addition, these often rely on single disease markers which are inappropriate when multiple factors are involved. Many diseases are a result of metabolic disorders, therefore it is logical to measure metabolism directly. One of the strategies employed by the emergent science of metabolomics is metabolic fingerprinting; which involves rapid, high-throughput global analysis to discriminate between samples of different biological status or origin. This review focuses on a selective number of recent studies where metabolic fingerprinting has been forwarded as a potential tool for disease diagnosis using infrared and Raman spectroscopies.
机译：快速，无创且明确地诊断疾病的早期发作的能力具有多种益处。这些措施包括早期干预治疗策略，以降低发病率和死亡率，并在负担过重的医疗保健系统内释放经济资源。已知当前正在使用的某些常规临床测试不合适或不可靠。另外，这些通常依赖于单一疾病标记，当涉及多个因素时，这些标记是不合适的。许多疾病是代谢紊乱的结果，因此直接测量代谢是合乎逻辑的。代谢组学新兴科学采用的策略之一是代谢指纹图谱。其中涉及快速，高通量的全局分析，以区分不同生物学状态或来源的样品。这篇综述集中在一些近期研究中，其中代谢指纹图谱已被转发为使用红外和拉曼光谱学进行疾病诊断的潜在工具。

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