...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Analyst: The Analytical Journal of the Royal Society of Chemistry: A Monthly International Publication Dealing with All Branches of Analytical Chemistry >Biosensing using plasmonic nanohole arrays with small, homogenous and tunable aperture diameters
【24h】

Biosensing using plasmonic nanohole arrays with small, homogenous and tunable aperture diameters

机译：使用具有小，均匀和可调孔径直径的等离子纳米孔阵列进行生物传感

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Plasmonic nanohole arrays are widely used for optical label-free molecular detection. An important factor for many applications is the diameter of the apertures. So far nanohole arrays with controllable diameters below 100 nm have not been demonstrated and it has not been systematically investigated how the diameter influences the optical properties. In this work we fine-tune the diameter in short range ordered nanohole arrays down to 50 nm. The experimental far field spectra show how the wavelength of maximum extinction remains unaffected while the transmission maximum blue shifts with smaller diameters. The near field is visualized by numerical simulations, showing a homogenous enhancement throughout the cylindrical void at the transmission maximum for diameters between 50 and 100 nm. For diameters below 50 nm plasmon excitation is no longer possible experimentally or by simulations. Further, we investigate the refractive index sensing capabilities of the smaller holes. As the diameter was reduced, the sensitivity in terms of resonance shift with bulk liquid refractive index was found to be unaltered. However, for the transmission maximum the sensitivity becomes more strongly localized to the hole interior. By directing molecular binding to the bottom of the holes we demonstrate how smaller holes enhance the sensitivity in terms of signal per molecule. A real-time detection limit well below one protein per nanohole is demonstrated. The smaller plasmonic nanoholes should be suitable for studies of molecules confined in small volumes and as mimics of biological nanopores.
机译：等离子体纳米孔阵列广泛用于无光学标记的分子检测。对于许多应用而言，重要的因素是孔的直径。迄今为止，尚未证明直径可控制在100 nm以下的纳米孔阵列，并且尚未系统研究直径如何影响光学性能。在这项工作中，我们将近距离有序纳米孔阵列的直径微调至50 nm。实验远场光谱表明，最大透射波长在较小直径的透射蓝移时如何保持最大消光波长不变。通过数值模拟将近场可视化，显示直径在50到100 nm之间的透射最大值时，整个圆柱孔处的均匀增强。对于直径小于50 nm的等离子体激元，不再可以通过实验或模拟进行激发。此外，我们研究了较小孔的折射率感应能力。随着直径减小，发现共振共振位移与整体液体折射率的关系没有改变。但是，对于最大透射率，灵敏度变得更加强烈地局限于孔内部。通过将分子结合引导到孔的底部，我们证明了较小的孔如何提高每个分子信号的灵敏度。实时检测限远远低于每个纳米孔一种蛋白质。较小的等离激元纳米孔应适合于研究限制在小体积内的分子，并适合作为生物纳米孔的模拟物。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号