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首页> 外文期刊>The Analyst: The Analytical Journal of the Royal Society of Chemistry: A Monthly International Publication Dealing with All Branches of Analytical Chemistry >Quantitative imaging of 2 nm monolayer-protected gold nanoparticle distributions in tissues using laser ablation inductively-coupled plasma mass spectrometry (LA-ICP-MS)
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Quantitative imaging of 2 nm monolayer-protected gold nanoparticle distributions in tissues using laser ablation inductively-coupled plasma mass spectrometry (LA-ICP-MS)

机译：使用激光消融电感耦合等离子体质谱（LA-ICP-MS）对组织中2 nm单层保护的金纳米颗粒分布进行定量成像

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摘要

Functionalized gold nanoparticles (AuNPs) have unique properties that make them important biomedical materials. Optimal use of these materials, though, requires an understanding of their fate in vivo. Here we describe the use of laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) to image the biodistributions of AuNPs in tissues from mice intravenously injected with AuNPs. We demonstrate for the first time that the distributions of very small (similar to 2 nm core) monolayer-protected AuNPs can be imaged in animal tissues at concentrations in the low parts-per-billion range. Moreover, the LA-ICP-MS images reveal that the monolayer coatings on the injected AuNPs influence their distributions, suggesting that the AuNPs remain intact in vivo and their surface chemistry influences how they interact with different organs. We also demonstrate that quantitative images of the AuNPs can be generated when the appropriate tissue homogenates are chosen for matrix matching. Overall, these results demonstrate the utility of LA-ICP-MS for tracking the fate of biomedically-relevant AuNPs in vivo, facilitating the design of improved AuNP-based therapeutics.
机译：功能化的金纳米粒子（AuNPs）具有使其成为重要的生物医学材料的独特性能。但是，这些材料的最佳使用需要了解它们在体内的命运。在这里，我们描述了使用激光消融电感耦合等离子体质谱（LA-ICP-MS）来成像AuNPs在静脉注射AuNPs的小鼠组织中的生物分布。我们首次证明了非常小的（类似于2 nm核）单层保护的AuNP的分布可以在动物组织中以低至十亿分之几的浓度成像。此外，LA-ICP-MS图像显示注入的AuNPs上的单层涂层会影响其分布，这表明AuNPs在体内仍保持完整，其表面化学性质会影响其与不同器官的相互作用。我们还表明，所述金纳米粒子的定量图像可以在适当的组织匀浆被选择用于基体匹配来生成。总体而言，这些结果证明了LA-ICP-MS在体内追踪与生物医学相关的AuNP的命运的实用性，从而有助于改进基于AuNP的治疗剂的设计。

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