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首页> 外文期刊>The Journal of Chemical Physics >Elongation/compaction of giant DNA caused by depletion interaction with a flexible polymer
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Elongation/compaction of giant DNA caused by depletion interaction with a flexible polymer

机译：与柔性聚合物的耗竭相互作用导致巨DNA的延伸/紧缩

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摘要

Structural changes in giant DNA induced by the addition of the flexible polymer Polyethylene Glycol (PEG) were examined by the method of single-DNA observation.In dilute DNA conditions,individual DNA assumes a compact state via a discrete coil-globule transition,whereas in concentrated solution,DNA molecules exhibit an extended conformation via macroscopic phase segregation.The long-axis length of the stretched state in DNA is about 10~3 times larger than that of the compact state.Phase segregation at high DNA concentrations occurs at lower PEG concentrations than the compaction at low DNA concentrations.These opposite changes in the conformation of DNA molecule are interpreted in terms of the free energy,including depletion interaction.
机译：通过单DNA观察的方法检查了通过添加柔性聚合物聚乙二醇（PEG）诱导的巨DNA的结构变化。在稀DNA条件下，单个DNA通过离散的线圈-球状转变而呈现致密状态，而在浓缩溶液中，DNA分子通过宏观相分离表现出延伸的构象.DNA中拉伸状态的长轴长度约为紧密状态的10〜3倍。高DNA浓度下的相分离发生在低PEG浓度下这些DNA分子构象的相反变化可以用自由能解释，包括耗尽相互作用。

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